| UniProt Protein Function: | NYREN18: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 7q36 Molecular Function:protein binding Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9Y5A7 |
| NCBI GenInfo Identifier: | 37154888 |
| NCBI Gene ID: | 51667 |
| NCBI Accession: | Q9Y5A7.2 |
| UniProt Secondary Accession: | Q9Y5A7,O95422, Q75MR9, Q8IX22, Q9BXR2, |
| UniProt Related Accession: | Q9Y5A7 |
| Molecular Weight: | 69,119 Da |
| NCBI Full Name: | NEDD8 ultimate buster 1 |
| NCBI Synonym Full Names: | negative regulator of ubiquitin like proteins 1 |
| NCBI Official Symbol: | NUB1 |
| NCBI Official Synonym Symbols: | BS4; NUB1L; NYREN18 |
| NCBI Protein Information: | NEDD8 ultimate buster 1 |
| UniProt Protein Name: | NEDD8 ultimate buster 1 |
| UniProt Synonym Protein Names: | Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18 |
| Protein Family: | NEDD8 ultimate buster |
| UniProt Gene Name: | NUB1 |
| UniProt Entry Name: | NUB1_HUMAN |
