Anti-NRTN Antibody (CAB16409)
- SKU:
- CAB16409
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NRTN Antibody |
| 抗体コード: | CAB16409 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human NRTN (NP_004549.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human NRTN (NP_004549.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ARPC GLRE LEVR VSEL GLGY ASDE TVLF RYCA GACE AAAR VYDL GLRR LRQR RRLR RERV RAQP CCRP TAYE DEVS FLDA HSRY HTVH ELSA RECA CV |
| 遺伝子ID: | 4902 |
| Uniprot: | Q99748 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 22kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | NRTN, NTN, neurturin |
| バックグラウンド: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. |
| UniProt Protein Function: | NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: axon; extracellular region Molecular Function:growth factor activity; receptor binding Biological Process: axon guidance; nervous system development; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Hirschsprung Disease, Susceptibility To, 1 |
| NCBI Summary: | Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99748 |
| NCBI GenInfo Identifier: | 2501180 |
| NCBI Gene ID: | 4902 |
| NCBI Accession: | Q99748.1 |
| UniProt Secondary Accession: | Q99748,B2RPE8, |
| UniProt Related Accession: | Q99748 |
| Molecular Weight: | 22,405 Da |
| NCBI Full Name: | Neurturin |
| NCBI Synonym Full Names: | neurturin |
| NCBI Official Symbol: | NRTN |
| NCBI Official Synonym Symbols: | NTN |
| NCBI Protein Information: | neurturin; prepro-neurturin |
| UniProt Protein Name: | Neurturin |
| Protein Family: | Neurturin |
| UniProt Gene Name: | NRTN |
| UniProt Entry Name: | NRTN_HUMAN |
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