| UniProt Protein Function: | RIP140: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 21q11.2 Cellular Component: cell junction; histone deacetylase complex; nuclear chromatin; nuclear speck; nucleolus; nucleoplasm; nucleus Molecular Function:androgen receptor binding; estrogen receptor binding; glucocorticoid receptor binding; histone deacetylase binding; nuclear hormone receptor binding; protein binding; retinoid X receptor binding; transcription coactivator activity; transcription corepressor activity Biological Process: androgen receptor signaling pathway; circadian regulation of gene expression; circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle rupture; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequestering of lipid; transcription, DNA-dependent |
| NCBI Summary: | Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48552 |
| NCBI GenInfo Identifier: | 9988061 |
| NCBI Gene ID: | 8204 |
| NCBI Accession: | P48552.2 |
| UniProt Secondary Accession: | P48552,Q8IWE8, |
| UniProt Related Accession: | P48552 |
| Molecular Weight: | 126,942 Da |
| NCBI Full Name: | Nuclear receptor-interacting protein 1 |
| NCBI Synonym Full Names: | nuclear receptor interacting protein 1 |
| NCBI Official Symbol: | NRIP1 |
| NCBI Official Synonym Symbols: | RIP140 |
| NCBI Protein Information: | nuclear receptor-interacting protein 1 |
| UniProt Protein Name: | Nuclear receptor-interacting protein 1 |
| UniProt Synonym Protein Names: | Nuclear factor RIP140; Receptor-interacting protein 140 |
| Protein Family: | Nuclear receptor-interacting protein |
| UniProt Gene Name: | NRIP1 |
| UniProt Entry Name: | NRIP1_HUMAN |
