Anti-NRG4 Antibody (CAB2599)
- SKU:
- CAB2599
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NRG4 Antibody |
| 抗体コード: | CAB2599 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human NRG4 (NP_612640.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, HepG2, BxPC-3, Rat thymus, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human NRG4 (NP_612640.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPTD HEEP CGPS HKSF CLNG GLCY VIPT IPSP FCRC VENY TGAR CEEV FLPG SSIQ TKSN LFEA FVAL AVLV TLII GAFY FLCR KGHF QRAS SVQY DINL VETS STSA HHSH EQH |
| 遺伝子ID: | 145957 |
| Uniprot: | Q8WWG1 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 12kDa |
| 観察された分子量: | 15kDa |
| 同義語: | NRG4, HRG4 |
| バックグラウンド: |
| UniProt Protein Function: | NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane Molecular Function:growth factor activity; receptor binding Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response |
| NCBI Summary: | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8WWG1 |
| NCBI GenInfo Identifier: | 28201832 |
| NCBI Gene ID: | 145957 |
| NCBI Accession: | Q8WWG1.1 |
| UniProt Secondary Accession: | Q8WWG1,A6NIE8, |
| UniProt Related Accession: | Q8WWG1 |
| Molecular Weight: | |
| NCBI Full Name: | Pro-neuregulin-4, membrane-bound isoform |
| NCBI Synonym Full Names: | neuregulin 4 |
| NCBI Official Symbol: | NRG4 |
| NCBI Official Synonym Symbols: | HRG4 |
| NCBI Protein Information: | pro-neuregulin-4, membrane-bound isoform; pro-NRG4; heregulin 4 |
| UniProt Protein Name: | Pro-neuregulin-4, membrane-bound isoform |
| Protein Family: | Pro-neuregulin |
| UniProt Gene Name: | NRG4 |
| UniProt Entry Name: | NRG4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NRG4 antibody (CAB2599) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
 | Immunohistochemistry of paraffin-embedded rat brain using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NRG4 antibody (CAB2599) at dilution of 1:100 (40x lens). |
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