Anti-NR2F6 Antibody (CAB15271)
- SKU:
- CAB15271
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-NR2F6 Antibody |
| 抗体コード: | CAB15271 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human NR2F6 (NP_005225.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human NR2F6 (NP_005225.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAMV TGGW GGPG GDTN GVDK AGGY PRAA EDDS ASPP GAAS DAEP GDEE RPGL QVD |
| 遺伝子ID: | 2063 |
| Uniprot: | P10588 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 50kDa |
| 同義語: | NR2F6, EAR-2, EAR2, ERBAL2 |
| バックグラウンド: |
| UniProt Protein Function: | EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| UniProt Protein Details: | Protein type:Nuclear receptor; DNA-binding Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; ligand-dependent nuclear receptor activity; protein binding; sequence-specific DNA binding; thyroid hormone receptor activity; transcription factor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter |
| UniProt Code: | P10588 |
| NCBI GenInfo Identifier: | 23503053 |
| NCBI Gene ID: | 2063 |
| NCBI Accession: | P10588.2 |
| UniProt Secondary Accession: | P10588,Q5XGA0, Q6P586, Q9BUE8, B2RC68, |
| UniProt Related Accession: | P10588 |
| Molecular Weight: | 42,979 Da |
| NCBI Full Name: | Nuclear receptor subfamily 2 group F member 6 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 2 group F member 6 |
| NCBI Official Symbol: | NR2F6 |
| NCBI Official Synonym Symbols: | EAR2; EAR-2; ERBAL2 |
| NCBI Protein Information: | nuclear receptor subfamily 2 group F member 6 |
| UniProt Protein Name: | Nuclear receptor subfamily 2 group F member 6 |
| UniProt Synonym Protein Names: | V-erbA-related protein 2; EAR-2 |
| Protein Family: | Nuclear receptor subfamily |
| UniProt Gene Name: | NR2F6 |
| UniProt Entry Name: | NR2F6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NR2F6 antibody (CAB15271) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1S. |
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