Anti-NPY1R Antibody (CAB3116)
- SKU:
- CAB3116
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NPY1R Antibody |
| 抗体コード: | CAB3116 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human NPY1R |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse fetal brain |
| 免疫原: | A synthetic peptide of human NPY1R |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4886 |
| Uniprot: | P25929 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 44kDa |
| 観察された分子量: | 44kDa |
| 同義語: | NPY1R, NPY1-R, NPYR |
| バックグラウンド: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. |
| UniProt Protein Function: | NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 4q31.3-q32 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain |
| NCBI Summary: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P25929 |
| NCBI GenInfo Identifier: | 128997 |
| NCBI Gene ID: | 4886 |
| NCBI Accession: | P25929.1 |
| UniProt Secondary Accession: | P25929,B2R6H5, |
| UniProt Related Accession: | P25929 |
| Molecular Weight: | 384 |
| NCBI Full Name: | Neuropeptide Y receptor type 1 |
| NCBI Synonym Full Names: | neuropeptide Y receptor Y1 |
| NCBI Official Symbol: | NPY1R |
| NCBI Official Synonym Symbols: | NPYR; NPY1-R |
| NCBI Protein Information: | neuropeptide Y receptor type 1 |
| UniProt Protein Name: | Neuropeptide Y receptor type 1 |
| Protein Family: | Neuropeptide Y receptor |
| UniProt Gene Name: | NPY1R |
| UniProt Entry Name: | NPY1R_HUMAN |
 | Western blot analysis of extracts of mouse fetal brain, using NPY1R antibody (CAB3116). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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