Anti-NPSR1 Antibody (CAB16619)
- SKU:
- CAB16619
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
| 抗体名: | Anti-NPSR1 Antibody |
| 抗体コード: | CAB16619 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse lung, Mouse thymus |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SKAK IKAI KYSI IIIL AFIC CWSP YFLF DILD NFNL LPDT QERF YASV IIQN LPAL NSAI NPLI YCVF SSSI SFPC REQR SQDS RMTF RERT ERHE MQIL SKPE FI |
| 遺伝子ID: | 387129 |
| Uniprot: | Q6W5P4 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Multi-pass membrane protein |
| 計算された分子量: | 10-18kDa, 35-44kDa |
| 観察された分子量: | 43kDa |
| 同義語: | NPSR1, ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1 |
| バックグラウンド: | This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NPSR1: May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 9 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:neuropeptide receptor activity Biological Process: positive regulation of release of sequestered calcium ion into cytosol Disease: Asthma-related Traits, Susceptibility To, 2 |
| NCBI Summary: | This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q6W5P4 |
| NCBI GenInfo Identifier: | 74758626 |
| NCBI Gene ID: | 387129 |
| NCBI Accession: | Q6W5P4.1 |
| UniProt Secondary Accession: | Q6W5P4,Q2XP58, Q56H76, Q56H77, Q56H78, Q6JSL4, Q6JSL5 Q6JSL6, Q6JSL7, Q6JSL8, Q6W5P3, A2RTZ4, |
| UniProt Related Accession: | Q6W5P4 |
| Molecular Weight: | 10,612 Da |
| NCBI Full Name: | Neuropeptide S receptor |
| NCBI Synonym Full Names: | neuropeptide S receptor 1 |
| NCBI Official Symbol: | NPSR1 |
| NCBI Official Synonym Symbols: | GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154 |
| NCBI Protein Information: | neuropeptide S receptor |
| UniProt Protein Name: | Neuropeptide S receptor |
| UniProt Synonym Protein Names: | G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility |
| Protein Family: | Neuropeptide S receptor |
| UniProt Gene Name: | NPSR1 |
| UniProt Entry Name: | NPSR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NPSR1 antibody (CAB16619) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |