Anti-NPFF Antibody (CAB7020)
- SKU:
- CAB7020
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NPFF Antibody |
| 抗体コード: | CAB7020 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | Rat plasma |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AEED SEPL PPQD AQTS GSLL HYLL QAME RPGR SQAF LFQP QRFG RNTQ GSWR NEWL SPRA GEGL NSQF WSLA APQR FGKK |
| 遺伝子ID: | 8620 |
| Uniprot: | O15130 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 12kDa |
| 観察された分子量: | 12kDa |
| 同義語: | NPFF, FMRFAL |
| バックグラウンド: | This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| UniProt Protein Function: | NPFF: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Belongs to the FARP (FMRFamide related peptide) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: extracellular space; dendrite; extracellular region; perikaryon; nerve terminal; vesicle Molecular Function:neuropeptide hormone activity; G-protein-coupled receptor binding; receptor binding Biological Process: response to drug; negative regulation of heart rate; maternal process involved in pregnancy; response to morphine; negative regulation of appetite; negative regulation of insulin secretion; vasopressin secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; spinal cord development; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; positive regulation of blood pressure; acute inflammatory response to antigenic stimulus |
| NCBI Summary: | This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O15130 |
| NCBI GenInfo Identifier: | 8134595 |
| NCBI Gene ID: | 8620 |
| NCBI Accession: | O15130.1 |
| UniProt Related Accession: | O15130 |
| Molecular Weight: | 12kDa |
| NCBI Full Name: | Pro-FMRFamide-related neuropeptide FF |
| NCBI Synonym Full Names: | neuropeptide FF-amide peptide precursor |
| NCBI Official Symbol: | NPFF |
| NCBI Official Synonym Symbols: | FMRFAL |
| NCBI Protein Information: | pro-FMRFamide-related neuropeptide FF |
| UniProt Protein Name: | Pro-FMRFamide-related neuropeptide FF |
| UniProt Synonym Protein Names: | FMRFamide-related peptidesCleaved into the following 3 chains:Neuropeptide SF; NPSF; Neuropeptide FF; NPFF; Neuropeptide AF; NPAF |
| Protein Family: | Pro-FMRFamide-related neuropeptide |
| UniProt Gene Name: | NPFF |
| UniProt Entry Name: | NPFF_HUMAN |
 | Western blot analysis of extracts of Rat plasma, using NPFF antibody (CAB7020) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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