Anti-NOXA1 Antibody (CAB13844)
- SKU:
- CAB13844
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-NOXA1 Antibody |
| 抗体コード: | CAB13844 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human NOXA1 (NP_006638.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HePG2, HT-29, DU145, Mouse stomach, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human NOXA1 (NP_006638.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EAAS SLRE AMSK WPEG SLNG LDSA LDQV QRRG SLPP RQVP RGEV FRPH RWHL KHLE PVDF LGKA KVVA SAIP DDQG WGVR PQQP QGPG ANHD ARSL IMDS PRAG THQG PLDA ETEV GADR CTST AYQE QRPQ VEQV GKQA PLSP GLPA MGGP GPGP CEDP A |
| 遺伝子ID: | 10811 |
| Uniprot: | Q86UR1 |
| セルラーロケーション: | Cell membrane, Cytoplasm |
| 計算された分子量: | 45kDa/50kDa/51kDa |
| 観察された分子量: | 51kDa |
| 同義語: | NOXA1, NY-CO-31, SDCCAG31, p51NOX |
| バックグラウンド: | This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NOXA1: Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. Belongs to the NCF2/NOXA1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Activator Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: cytoplasm; NADPH oxidase complex Molecular Function:protein binding; enzyme binding; Rac GTPase binding; superoxide-generating NADPH oxidase activator activity; SH3 domain binding Biological Process: positive regulation of catalytic activity; superoxide metabolic process; regulation of hydrogen peroxide metabolic process |
| NCBI Summary: | This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q86UR1 |
| NCBI GenInfo Identifier: | 74759404 |
| NCBI Gene ID: | 10811 |
| NCBI Accession: | Q86UR1.1 |
| UniProt Secondary Accession: | Q86UR1,Q8CJ00, A7E3N7, |
| UniProt Related Accession: | Q86UR1 |
| Molecular Weight: | 45,245 Da |
| NCBI Full Name: | NADPH oxidase activator 1 |
| NCBI Synonym Full Names: | NADPH oxidase activator 1 |
| NCBI Official Symbol: | NOXA1 |
| NCBI Official Synonym Symbols: | p51NOX; NY-CO-31; SDCCAG31 |
| NCBI Protein Information: | NADPH oxidase activator 1; p51-nox; Nox activator 1; antigen NY-CO-31; NCF2-like protein; p67phox-like factor; inhibitory NADPH oxidase activator 1; serologically defined colon cancer antigen 31 |
| UniProt Protein Name: | NADPH oxidase activator 1 |
| UniProt Synonym Protein Names: | Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-nox |
| Protein Family: | NADPH oxidase activator |
| UniProt Gene Name: | NOXA1 |
| UniProt Entry Name: | NOXA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NOXA1 antibody (CAB13844) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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