| バックグラウンド: | This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. |
| UniProt Protein Function: | NOX3: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oxidoreductase; EC 1.6.3.-; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: plasma membrane |
| NCBI Summary: | This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009] |
| UniProt Code: | Q9HBY0 |
| NCBI GenInfo Identifier: | 74752785 |
| NCBI Gene ID: | 50508 |
| NCBI Accession: | Q9HBY0.1 |
| UniProt Secondary Accession: | Q9HBY0,Q9HBJ9, |
| UniProt Related Accession: | Q9HBY0 |
| Molecular Weight: | 64,935 Da |
| NCBI Full Name: | NADPH oxidase 3 |
| NCBI Synonym Full Names: | NADPH oxidase 3 |
| NCBI Official Symbol: | NOX3 |
| NCBI Official Synonym Symbols: | MOX-2; GP91-3 |
| NCBI Protein Information: | NADPH oxidase 3 |
| UniProt Protein Name: | NADPH oxidase 3 |
| UniProt Synonym Protein Names: | Mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3 |
| Protein Family: | NADPH oxidase |
| UniProt Gene Name: | NOX3 |
| UniProt Entry Name: | NOX3_HUMAN |
