Anti-NNT Antibody (CAB4561)
- SKU:
- CAB4561
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NNT
- Synonyms:
- GCCD4
Frequently bought together:
Description
| 抗体名: | NNT Rabbit pAb |
| 抗体コード: | CAB4561 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | NNT, GCCD4 |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 881-1086 of human NNT (NP_036475.3). |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse heart, Mouse liver, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 881-1086 of human NNT (NP_036475.3). |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NRSL ANVI LGGY GTTS TAGG KPME ISGT HTEI NLDN AIDM IREA NSII ITPG YGLC AAKA QYPI ADLV KMLT EQGK KVRF GIHP VAGR MPGQ LNVL LAEA GVPY DIVL EMDE INHD FPDT DLVL VIGA NDTV NSAA QEDP NSII AGMP VLEV WKSK QVIV MKRS LGVG YAAV DNPI FYKP NTAM LLGD AKKT CDAL QAKV RESY QK |
| 遺伝子ID: | 23530 |
| Uniprot: | Q13423 |
| セルラーロケーション: | Matrix side, Mitochondrion inner membrane, Multi-pass membrane protein |
| 計算された分子量: | 113kDa |
| 観察された分子量: | 114kDa/125kDa |
| UniProt Protein Function: | NNT: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. Defects in NNT are the cause of glucocorticoid deficiency type 4 (GCCD4). A rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Mitochondrial; EC 1.6.1.2; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 5p12 Cellular Component: mitochondrion; membrane; mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chain Molecular Function:NAD(P) transhydrogenase activity; NAD(P)+ transhydrogenase (AB-specific) activity; NADP binding; NAD binding; NAD(P)+ transhydrogenase (B-specific) activity Biological Process: cellular metabolic process; proton transport; cell redox homeostasis; tricarboxylic acid cycle Disease: Glucocorticoid Deficiency 4 |
| NCBI Summary: | This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13423 |
| NCBI GenInfo Identifier: | 51338801 |
| NCBI Gene ID: | 23530 |
| NCBI Accession: | Q13423.3 |
| UniProt Secondary Accession: | Q13423,Q16796, Q2TB60, Q8N3V4, |
| UniProt Related Accession: | Q13423 |
| Molecular Weight: | 1086 |
| NCBI Full Name: | NAD(P) transhydrogenase, mitochondrial |
| NCBI Synonym Full Names: | nicotinamide nucleotide transhydrogenase |
| NCBI Official Symbol: | NNT |
| NCBI Official Synonym Symbols: | GCCD4 |
| NCBI Protein Information: | NAD(P) transhydrogenase, mitochondrial; NAD(P) transhydrogenase, mitochondrial; pyridine nucleotide transhydrogenase |
| UniProt Protein Name: | NAD(P) transhydrogenase, mitochondrial |
| UniProt Synonym Protein Names: | Nicotinamide nucleotide transhydrogenase; Pyridine nucleotide transhydrogenase |
| Protein Family: | NAD(P) transhydrogenase |
| UniProt Gene Name: | NNT |
| UniProt Entry Name: | NNTM_HUMAN |