Anti-NLRP10 Antibody (CAB15976)
- SKU:
- CAB15976
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-NLRP10 Antibody |
| 抗体コード: | CAB15976 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NLRP10 (NP_789791.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, LO2, HT-29 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NLRP10 (NP_789791.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAMA KARK PREA LLWA LSDL EEND FKKL KFYL RDMT LSEG QPPL ARGE LEGL IPVD LAEL LISK YGEK EAVK VVLK GLKV MNLL ELVD QLSH ICLH DYRE VYRE HVRC LEEW QEAG VNGR YNQV LLVA KPSS ESPE SLAC PFPE QELE SVTV EALF DSGE KPSL APSL VVLQ GSAG TGKT TLAR KMVL DWAT GTLY PGRF DYVF YVSC KEVV LLLE SKLE QLLF WCCG DNQA PVTE ILRQ PERL LFIL DGFD ELQR PFEE KLKK RGLS PKES LLHL LIRR HTLP TCSL LITT RPLA LRNL |
| 遺伝子ID: | 338322 |
| Uniprot: | Q86W26 |
| セルラーロケーション: | Cell membrane, Cytoplasm |
| 計算された分子量: | 75kDa |
| 観察された分子量: | 75kDa |
| 同義語: | NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD |
| バックグラウンド: | Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. |
| UniProt Protein Function: | NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytoplasm; extrinsic to plasma membrane Biological Process: defense response to fungus; defense response to Gram-negative bacterium; positive regulation of T-helper 1 type immune response |
| NCBI Summary: | Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86W26 |
| NCBI GenInfo Identifier: | 46396380 |
| NCBI Gene ID: | 338322 |
| NCBI Accession: | Q86W26.1 |
| UniProt Secondary Accession: | Q86W26,Q2M3C4, Q6JGT0, |
| UniProt Related Accession: | Q86W26 |
| Molecular Weight: | 75,032 Da |
| NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 10 |
| NCBI Synonym Full Names: | NLR family pyrin domain containing 10 |
| NCBI Official Symbol: | NLRP10 |
| NCBI Official Synonym Symbols: | NOD8; PAN5; PYNOD; NALP10; CLR11.1 |
| NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 10 |
| UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 10 |
| UniProt Synonym Protein Names: | Nucleotide-binding oligomerization domain protein 8 |
| Protein Family: | NACHT, LRR and PYD domains-containing protein |
| UniProt Gene Name: | NLRP10 |
| UniProt Entry Name: | NAL10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NLRP10 antibody (CAB15976) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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