Anti-NLGN3 Antibody (CAB10310)
- SKU:
- CAB10310
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NLGN3 Antibody |
| 抗体コード: | CAB10310 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human NLGN3 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, K-562, Mouse brain, Mouse liver |
| 免疫原: | Recombinant protein of human NLGN3 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 54413 |
| Uniprot: | Q9NZ94 |
| セルラーロケーション: | Cell junction, Cell membrane, Single-pass type I membrane protein, synapse |
| 計算された分子量: | 89kDa/91kDa/93kDa |
| 観察された分子量: | 108kDa |
| 同義語: | NLGN3, HNL3 |
| バックグラウンド: | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: cell surface; endocytic vesicle; excitatory synapse; integral to plasma membrane; plasma membrane; synapse Molecular Function:cell adhesion molecule binding; neurexin binding; protein binding; receptor activity Biological Process: adult behavior; axon extension; learning; neurological control of breathing; neuron adhesion; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; receptor-mediated endocytosis; regulation of inhibitory postsynaptic membrane potential; regulation of synaptic transmission; rhythmic synaptic transmission; social behavior; synapse organization and biogenesis; synaptogenesis Disease: Asperger Syndrome, X-linked, Susceptibility To, 1; Autism, Susceptibility To, X-linked 1 |
| NCBI Summary: | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9NZ94 |
| NCBI GenInfo Identifier: | 31076855 |
| NCBI Gene ID: | 54413 |
| NCBI Accession: | Q9NZ94.2 |
| UniProt Secondary Accession: | Q9NZ94,Q86V51, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248 B2RBK1, D2X2H6, D3DVV0, D3DVV1, |
| UniProt Related Accession: | Q9NZ94 |
| Molecular Weight: | 94kDa |
| NCBI Full Name: | Neuroligin-3 |
| NCBI Synonym Full Names: | neuroligin 3 |
| NCBI Official Symbol: | NLGN3 |
| NCBI Official Synonym Symbols: | HNL3 |
| NCBI Protein Information: | neuroligin-3 |
| UniProt Protein Name: | Neuroligin-3 |
| UniProt Synonym Protein Names: | Gliotactin homolog |
| Protein Family: | Neuroligin |
| UniProt Gene Name: | NLGN3 |
 | Western blot analysis of extracts of various cell lines, using NLGN3 antibody (CAB10310) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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