Anti-NHEJ1 Antibody (CAB4985)

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SKU:
CAB4985
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NHEJ1
Synonyms:
XLF
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Description

I抗体名:NHEJ1 Rabbit pAb
抗体コード:CAB4985
サイズ:20uL, 50uL, 100uL
同義語:NHEJ1, XLF
申し込み:WB, IHC, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human NHEJ1 (NP_079058.1).
申し込み:WB, IHC, IF
推奨される希釈:WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:Hela, Jurkat
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human NHEJ1 (NP_079058.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MEEL EQGL LMQP WAWL QLAE NSLL AKVF ITKQ GYAL LVSD LQQV WHEQ VDTS VVSQ RAKE LNKR LTAP PAAF LCHL DNLL RPLL KDAA HPSE ATFS CDCV ADAL ILRV RSEL SGLP FYWN FHCM LASP SLVS QHLI RPLM GMSL ALQC QVRE LATL LHMK DLEI QDYQ ESGA TLIR DRLK TEPF EENS FLEQ FMIE KLPE ACSI GDGK PFVM NLQD LYMA VTTQ EVQV GQKH QGAG DPHT SNSA SLQG IDSQ CVNQ PEQL VSSA PTLS APEK ESTG TSGP LQRP QLSK VKRK KPRG LFS
遺伝子ID:79840
Uniprot:Q9H9Q4
セルラーロケーション:Nucleus
計算された分子量:33kDa/35kDa
観察された分子量:38kDa
UniProt Protein Function:NHEJ1: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner. Ubiquitously expressed. Belongs to the XLF family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA repair, damage

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nucleus

Molecular Function:protein binding; DNA binding

Biological Process: central nervous system development; B cell differentiation; response to ionizing radiation; positive regulation of ligase activity; double-strand break repair via nonhomologous end joining; DNA recombination; T cell differentiation

Disease: Severe Combined Immunodeficiency With Microcephaly, Growth Retardation, And Sensitivity To Ionizing Radiation

NCBI Summary:Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H9Q4
NCBI GenInfo Identifier:74734059
NCBI Gene ID:79840
NCBI Accession:Q9H9Q4.1
UniProt Secondary Accession:Q9H9Q4,Q4ZFW7, Q6IA64, Q96JS9, B8ZZA4,
UniProt Related Accession:Q9H9Q4
Molecular Weight:299
NCBI Full Name:Non-homologous end-joining factor 1
NCBI Synonym Full Names:nonhomologous end-joining factor 1
NCBI Official Symbol:NHEJ1  
NCBI Official Synonym Symbols:XLF  
NCBI Protein Information:non-homologous end-joining factor 1; XRCC4-like factor; protein cernunnos
UniProt Protein Name:Non-homologous end-joining factor 1
UniProt Synonym Protein Names:Protein cernunnos; XRCC4-like factor
Protein Family:Non-homologous end-joining factor
UniProt Gene Name:NHEJ1  
UniProt Entry Name:NHEJ1_HUMAN
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