| UniProt Protein Function: | NEK6: a protein kinase of the NEK family. Important in mitosis. May regulate spindle function. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Other group; NEK family Chromosomal Location of Human Ortholog: 9q33.3-q34.11 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; microtubule organizing center; nucleoplasm; nucleus Molecular Function:ATP binding; kinesin binding; magnesium ion binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity Biological Process: chromosome segregation; cytokinesis; G2/M transition DNA damage checkpoint; mitotic nuclear envelope disassembly; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; spindle assembly |
| NCBI Summary: | The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9HC98 |
| NCBI GenInfo Identifier: | 37537993 |
| NCBI Gene ID: | 10783 |
| NCBI Accession: | Q9HC98.2 |
| UniProt Secondary Accession: | Q9HC98,Q5TBG3, Q5TBG9, Q6FG86, Q6IAR3, Q96E83, Q9ULX2 B7Z2D9, |
| UniProt Related Accession: | Q9HC98 |
| Molecular Weight: | 38,460 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Nek6 |
| NCBI Synonym Full Names: | NIMA related kinase 6 |
| NCBI Official Symbol: | NEK6 |
| NCBI Official Synonym Symbols: | SID6-1512 |
| NCBI Protein Information: | serine/threonine-protein kinase Nek6 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek6 |
| UniProt Synonym Protein Names: | Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | NEK6 |
| UniProt Entry Name: | NEK6_HUMAN |
