Anti-NEDD9 Antibody (CAB12010)
- SKU:
- CAB12010
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NEDD9 Antibody |
| 抗体コード: | CAB12010 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human NEDD9 (NP_892011.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | B-cell |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human NEDD9 (NP_892011.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKYK NLMA RALY DNVP ECAE ELAF RKGD ILTV IEQN TGGL EGWW LCSL HGRQ GIVP GNRV KLLI GPMQ ETAS SHEQ PASG LMQQ TFGQ QKLY QVPN PQAA PRDT IYQV PPSY QNQG IYQV PTGH GTQE QEVY QVPP SVQR SIGG TSGP HVGK KV |
| 遺伝子ID: | 4739 |
| Uniprot: | Q14511 |
| セルラーロケーション: | Cell junction, Cell projection, Cytoplasm, Golgi apparatus, Nucleus, cell cortex, cytoskeleton, focal adhesion, lamellipodium, spindle |
| 計算された分子量: | 19kDa/92kDa |
| 観察された分子量: | 105kDa |
| 同義語: | NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1 |
| バックグラウンド: | The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Cas-L: a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 6p24.2 Cellular Component: spindle pole; Golgi apparatus; focal adhesion; lamellipodium; cytoplasm; spindle; cell cortex; nucleus Molecular Function:protein binding Biological Process: integrin-mediated signaling pathway; mitosis; actin filament bundle formation; cell division; regulation of growth; cytoskeleton organization and biogenesis; signal transduction; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q14511 |
| NCBI GenInfo Identifier: | 8134360 |
| NCBI Gene ID: | 4739 |
| NCBI Accession: | Q14511.1 |
| UniProt Related Accession: | Q14511 |
| Molecular Weight: | |
| NCBI Full Name: | Enhancer of filamentation 1 |
| NCBI Synonym Full Names: | neural precursor cell expressed, developmentally down-regulated 9 |
| NCBI Official Symbol: | NEDD9 |
| NCBI Official Synonym Symbols: | CAS2; CASL; HEF1; CAS-L; CASS2 |
| NCBI Protein Information: | enhancer of filamentation 1 |
| UniProt Protein Name: | Enhancer of filamentation 1 |
| UniProt Synonym Protein Names: | CRK-associated substrate-related protein; CAS-L; CasL; Cas scaffolding protein family member 2; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; Renal carcinoma antigen NY-REN-12; p105Enhancer of filamentation 1 p55 |
| UniProt Gene Name: | NEDD9 |
| UniProt Entry Name: | CASL_HUMAN |
 | Western blot analysis of extracts of B-cell cells, using NEDD9 Antibody (CAB12010) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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