Anti-NDUFV2 Antibody (CAB19936)[KO Validated]
![Anti-NDUFV2 Antibody (CAB19936)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/18560/18426/anti-ndufv2-antibody-cab19936ko-validated__65105__73616.1645803991.jpg?c=1 "Anti-NDUFV2 Antibody (CAB19936)[KO Validated]")
- SKU:
- CAB19936
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-NDUFV2 Antibody (CAB19936)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/18560/18426/anti-ndufv2-antibody-cab19936ko-validated__65105__73616.1645803991.jpg?c=1&imbypass=on "Anti-NDUFV2 Antibody (CAB19936)[KO Validated]")
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Description
| 抗体名: | Anti-NDUFV2 Antibody [KO Validated] |
| 抗体コード: | CAB19936 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human NDUFV2. |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human NDUFV2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4729 |
| Uniprot: | P19404 |
| セルラーロケーション: | Mitochondrion inner membrane |
| 計算された分子量: | 27kDa |
| 観察された分子量: | 24KDa |
![Anti-NDUFV2 Antibody [KO Validated] (CAB19936)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/s/501/A19936_1__21862.jpg) | Western blot analysis of extracts from normal (control) and NDUFV2 knockout (KO) HeLa cells, using NDUFV2 antibody (CAB19936) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | NDUFV2, CI-24k |
| バックグラウンド: | The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. |
| UniProt Protein Function: | NDUFV2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 24 kDa subunit family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Mitochondrial; EC 1.6.99.3; EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 18p11.22 Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex I Molecular Function:2 iron, 2 sulfur cluster binding; electron carrier activity; NADH dehydrogenase (ubiquinone) activity; metal ion binding Biological Process: cardiac muscle development; cellular metabolic process; nervous system development; mitochondrial electron transport, NADH to ubiquinone Disease: Mitochondrial Complex I Deficiency |
| NCBI Summary: | The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P19404 |
| NCBI GenInfo Identifier: | 20455499 |
| NCBI Gene ID: | 4729 |
| NCBI Accession: | P19404.2 |
| UniProt Secondary Accession: | P19404,Q9BV41, |
| UniProt Related Accession: | P19404 |
| Molecular Weight: | 249 |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa |
| NCBI Official Symbol: | NDUFV2 |
| NCBI Official Synonym Symbols: | CI-24k |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; complex I 24kDa subunit; NADH-ubiquinone oxidoreductase 24 kDa subunit; NADH-ubiquinone oxidoreductase flavoprotein 2; complex I, mitochondrial respitory chain, 24 kD subunit; NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial; nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial |
| UniProt Synonym Protein Names: | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| Protein Family: | NADH dehydrogenase [ubiquinone] flavoprotein |
| UniProt Gene Name: | NDUFV2 |
| UniProt Entry Name: | NDUV2_HUMAN |