Anti-NDST1 Antibody (CAB17498)
- SKU:
- CAB17498
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-NDST1 Antibody |
抗体コード: | CAB17498 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-170 of human NDST1 (NP_001534.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-170 of human NDST1 (NP_001534.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GWKR GLEP SADA PEPD CGDP PPVA PSRL LPLK PVQA ATPS RTDP LVLV FVES LYSQ LGQE VVAI LESS RFKY RTEI APGK GDMP TLTD KGRG RFAL IIYE NILK YVNL DAWN RELL DKYC VAYG VGII GFF |
遺伝子ID: | 3340 |
Uniprot: | P52848 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | Refer to figures |
同義語: | HSST, MRT46, NST1, NDST1 |
バックグラウンド: | This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Protein Function: | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
NCBI Summary: | This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P52848 |
NCBI GenInfo Identifier: | 4505351 |
NCBI Gene ID: | 3340 |
NCBI Accession: | NP_001534.1 |
UniProt Secondary Accession: | P52848,Q96E57, |
UniProt Related Accession: | P52848 |
Molecular Weight: | 62,065 Da |
NCBI Full Name: | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1 |
NCBI Synonym Full Names: | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 |
NCBI Official Symbol: | NDST1 |
NCBI Official Synonym Symbols: | HSST; NST1 |
NCBI Protein Information: | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosam |
UniProt Protein Name: | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 |
UniProt Synonym Protein Names: | Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1 |
UniProt Gene Name: | NDST1 |