Anti-NCOR1 Antibody (CAB7046)
- SKU:
- CAB7046
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NCOR1 Antibody |
| 抗体コード: | CAB7046 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NCOR1 (NP_006302.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NCOR1 (NP_006302.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSSS GYPP NQGA FSTE QSRY PPHS VQYT FPNT RHQQ EFAV PDYR SSHL EVSQ ASQL LQQQ QQQQ LRRR PSLL SEFH PGSD RPQE RRTS YEPF HPGP SPVD HDSL ESKR PRLE QVSD SHFQ RVSA AVLP LVHP LPEG LRAS ADAK KDPA FGGK HEAP SSPI SGQP CGDD QNAS PSKL SKEE LIQS MDRV DREI AKVE QQIL |
| 遺伝子ID: | 9611 |
| Uniprot: | O75376 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 103kDa/258kDa/270kDa |
| 観察された分子量: | 270KDa |
| 同義語: | NCOR1, N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR |
| バックグラウンド: | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. |
| UniProt Protein Function: | N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; Sin3 complex; spindle microtubule; transcriptional repressor complex Molecular Function:histone deacetylase binding; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; protein binding; thyroid hormone receptor binding; transcription corepressor activity Biological Process: cellular lipid metabolic process; circadian rhythm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010] |
| UniProt Code: | O75376 |
| NCBI GenInfo Identifier: | 47117817 |
| NCBI Gene ID: | 9611 |
| NCBI Accession: | O75376.2 |
| UniProt Secondary Accession: | O75376,Q86YY0, Q9UPV5, Q9UQ18, B3DLF8, E9PGV6, |
| UniProt Related Accession: | O75376 |
| Molecular Weight: | |
| NCBI Full Name: | Nuclear receptor corepressor 1 |
| NCBI Synonym Full Names: | nuclear receptor corepressor 1 |
| NCBI Official Symbol: | NCOR1 |
| NCBI Official Synonym Symbols: | N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109 |
| NCBI Protein Information: | nuclear receptor corepressor 1 |
| UniProt Protein Name: | Nuclear receptor corepressor 1 |
| Protein Family: | Nuclear receptor corepressor |
| UniProt Gene Name: | NCOR1 |
| UniProt Entry Name: | NCOR1_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using NCOR1 antibody (CAB7046) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat stomach using NCOR1 Rabbit pAb (CAB7046) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using NCOR1 Rabbit pAb (CAB7046) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using NCOR1 Rabbit pAb (CAB7046) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using NCOR1 antibody (CAB7046). Blue: DAPI for nuclear staining. |
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