Anti-NCOA4 Antibody (CAB5695)[KO Validated]
![Anti-NCOA4 Antibody (CAB5695)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/22788/22636/anti-ncoa4-antibody-cab5695ko-validated__17521__86955.1645805521.jpg?c=1 "Anti-NCOA4 Antibody (CAB5695)[KO Validated]")
- SKU:
- CAB5695
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
![Anti-NCOA4 Antibody (CAB5695)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/22788/22636/anti-ncoa4-antibody-cab5695ko-validated__17521__86955.1645805521.jpg?c=1&imbypass=on "Anti-NCOA4 Antibody (CAB5695)[KO Validated]")
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Description
| 抗体名: | Anti-NCOA4 Antibody [KO Validated] |
| 抗体コード: | CAB5695 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 495-614 of human NCOA4 (NP_005428.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A375, HeLa, MCF7, 293T, Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 495-614 of human NCOA4 (NP_005428.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SEWL IRPP YKEG SPKE VPGT EDRA GKQK FKSP MNTS WCSF NTAD WVLP GKKM GNLS QLSS GEDK WLLR KKAQ EVLL NSPL QEEH NFPP DHYG LPAV CDLF ACMQ LKVD KEKW LYRT PLQM |
| 遺伝子ID: | 8031 |
| Uniprot: | Q13772 |
| セルラーロケーション: | |
| 計算された分子量: | 32kDa/69kDa/71kDa/73kDa |
| 観察された分子量: | 70kDa |
| 同義語: | NCOA4, ARA70, ELE1, PTC3, RFG |
| バックグラウンド: | This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. |
| UniProt Protein Function: | NCOA4: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: nucleus Biological Process: male gonad development Disease: Thyroid Carcinoma, Papillary |
| NCBI Summary: | This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q13772 |
| NCBI GenInfo Identifier: | 8928226 |
| NCBI Gene ID: | 8031 |
| NCBI Accession: | Q13772.1 |
| UniProt Secondary Accession: | Q13772,Q14239, A8K8W5, B4E260, E9PAV7, J3KQN8, |
| UniProt Related Accession: | Q13772 |
| Molecular Weight: | 73,649 Da |
| NCBI Full Name: | Nuclear receptor coactivator 4 |
| NCBI Synonym Full Names: | nuclear receptor coactivator 4 |
| NCBI Official Symbol: | NCOA4 |
| NCBI Official Synonym Symbols: | RFG; ELE1; PTC3; ARA70 |
| NCBI Protein Information: | nuclear receptor coactivator 4 |
| UniProt Protein Name: | Nuclear receptor coactivator 4 |
| UniProt Synonym Protein Names: | Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1 |
| Protein Family: | Nuclear receptor coactivator |
| UniProt Gene Name: | NCOA4 |
| UniProt Entry Name: | NCOA4_HUMAN |
![Anti-NCOA4 Antibody [KO Validated] (CAB5695)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/j/121/A5695_1__22905.jpg) | Western blot analysis of extracts of various cell lines, using NCOA4 antibody (CAB5695) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
![Anti-NCOA4 Antibody [KO Validated] (CAB5695)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/c/861/A5695_2__25262.jpg) | Western blot analysis of extracts from normal (control) and NCOA4 knockout (KO) HeLa cells, using NCOA4 antibody (CAB5695) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
![Anti-NCOA4 Antibody [KO Validated] (CAB5695)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/m/803/A5695_3__02894.jpg) | Immunohistochemistry of paraffin-embedded human lung cancer using NCOA4 antibody (CAB5695) at dilution of 1:100 (40x lens). |
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