Anti-NABP2 Antibody (CAB18488)
- SKU:
- CAB18488
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-NABP2 Antibody |
| 抗体コード: | CAB18488 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human NABP2. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human NABP2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 79035 |
| Uniprot: | Q9BQ15 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | OBFC2B, SOSS-B1, SSB1, hSSB1, NABP2 |
| バックグラウンド: |
| UniProt Protein Function: | OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Cell cycle regulation Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:enzyme binding; protein binding; single-stranded DNA binding Biological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; regulation of telomerase activity; response to DNA damage stimulus; response to ionizing radiation; snRNA transcription from RNA polymerase II promoter |
| NCBI Summary: | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] |
| UniProt Code: | Q9BQ15 |
| NCBI GenInfo Identifier: | 74761196 |
| NCBI Gene ID: | 79035 |
| NCBI Accession: | Q9BQ15.1 |
| UniProt Secondary Accession: | Q9BQ15,Q6XYC8, A6NDF8, |
| UniProt Related Accession: | Q9BQ15 |
| Molecular Weight: | 11,493 Da |
| NCBI Full Name: | SOSS complex subunit B1 |
| NCBI Synonym Full Names: | nucleic acid binding protein 2 |
| NCBI Official Symbol: | NABP2 |
| NCBI Official Synonym Symbols: | SSB1; hSSB1; OBFC2B; SOSS-B1 |
| NCBI Protein Information: | SOSS complex subunit B1 |
| UniProt Protein Name: | SOSS complex subunit B1 |
| UniProt Synonym Protein Names: | Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1 |
| Protein Family: | SOSS complex |
| UniProt Gene Name: | NABP2 |
| UniProt Entry Name: | SOSB1_HUMAN |