Anti-MYPN Antibody (CAB16584)
- SKU:
- CAB16584
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYPN Antibody |
| 抗体コード: | CAB16584 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MYPN (NP_115967.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MYPN (NP_115967.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MQDD SIEA STSI SQLL RESY LAET RHRG NNER SRAE PSSN PCHF GSPS GAAE GGGG QDDL PDLS AFLS QEEL DESV NLAR LAIN YDPL EKAD ETQA RKRL SPDQ MKHS PNLS FEPN FCQD NPRS PTSS KESP QEAK RPQY CSET QSKK VFLN KAAD FIEE LSSL FKSH SSKR IRPR ACKN HKSK LESQ NKVM QENS SSFS DLSE RRER SSVP IPIP ADTR DNEV NHAL EQQE AKRR EAEQ AASE AAGG DT |
| 遺伝子ID: | 84665 |
| Uniprot: | Q86TC9 |
| セルラーロケーション: | Cytoplasm, Nucleus, myofibril, sarcomere |
| 計算された分子量: | 56kDa/114kDa/145kDa |
| 観察された分子量: | 145kDa |
| 同義語: | MYPN, CMD1DD, CMH22, MYOP, NEM11, RCM4 |
| バックグラウンド: | Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MYPN: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Belongs to the myotilin/palladin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: I band; nucleus; Z disc Molecular Function:cytoskeletal protein binding; muscle alpha-actinin binding; protein binding; SH3 domain binding Biological Process: sarcomere organization Disease: Cardiomyopathy, Dilated, 1kk |
| NCBI Summary: | Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q86TC9 |
| NCBI GenInfo Identifier: | 13957727 |
| NCBI Gene ID: | 84665 |
| NCBI Accession: | AAK50625.1 |
| UniProt Secondary Accession: | Q86TC9,Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5 |
| UniProt Related Accession: | Q86TC9 |
| Molecular Weight: | |
| NCBI Full Name: | myopalladin |
| NCBI Synonym Full Names: | myopalladin |
| NCBI Official Symbol: | MYPN |
| NCBI Official Synonym Symbols: | MYOP; RCM4; CMH22; NEM11; CMD1DD |
| NCBI Protein Information: | myopalladin |
| UniProt Protein Name: | Myopalladin |
| UniProt Synonym Protein Names: | 145 kDa sarcomeric protein |
| Protein Family: | Myopalladin |
| UniProt Gene Name: | MYPN |
 | Western blot analysis of extracts of HepG2 cells, using MYPN antibody (CAB16584) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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