Anti-MYO7A Antibody (CAB1911)
- SKU:
- CAB1911
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-MYO7A Antibody |
| 抗体コード: | CAB1911 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-1150 of human MYO7A (NP_000251.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-1150 of human MYO7A (NP_000251.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MIAR RLHQ RLRA EYLW RLEA EKMR LAEE EKLR KEMS AKKA KEEA ERKH QERL AQLA REDA EREL KEKE AARR KKEL LEQM ERAR HEPV NHSD MVDK MFGF LGTS GGLP GQEG QAPS GFED LERG RREM VEED LDAA LPLP DEDE EDLS EYKF AKFA ATYF QGTT THSY TRRP LKQP LLYH DDEG DQLA ALAV WITI LRFM GDLP EPKY HTAM SDGS EKIP VMTK IYET LGKK TYKR ELQA LQGE GEAQ LPEG QKKS SVRH KLVH LTLK KKSK LTEE VTKR LHDG ESTV QGNS MLED RPTS N |
| 遺伝子ID: | 4647 |
| Uniprot: | Q13402 |
| セルラーロケーション: | Cytoplasm, cell cortex, cytoskeleton |
| 計算された分子量: | 138kDa/240kDa/249kDa/250kDa/254kDa |
| 観察された分子量: | 254kDa |
| 同義語: | MYO7A, DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B |
| バックグラウンド: | This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: stereocilium; photoreceptor inner segment; photoreceptor outer segment; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium Molecular Function:actin filament binding; microfilament motor activity; calmodulin binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; ADP binding; actin-dependent ATPase activity; ATP binding Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; actin filament-based movement; lysosome organization and biogenesis; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I |
| NCBI Summary: | This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13402 |
| NCBI GenInfo Identifier: | 460018219 |
| NCBI Gene ID: | 4647 |
| NCBI Accession: | Q13402.2 |
| UniProt Related Accession: | Q13402 |
| Molecular Weight: | |
| NCBI Full Name: | Unconventional myosin-VIIa |
| NCBI Synonym Full Names: | myosin VIIA |
| NCBI Official Symbol: | MYO7A |
| NCBI Official Synonym Symbols: | DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA |
| NCBI Protein Information: | unconventional myosin-VIIa |
| UniProt Protein Name: | Unconventional myosin-VIIa |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO7A |
| UniProt Entry Name: | MYO7A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MYO7A antibody (CAB1911) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |