Anti-MYO5A Antibody (CAB9830)
- SKU:
- CAB9830
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYO5A Antibody |
| 抗体コード: | CAB9830 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human MYO5A (NP_000250.3). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Jurkat, MCF7, HT-1080, Mouse spleen, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human MYO5A (NP_000250.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LTNL EGIY NSET EKLR SDLE RLQL SEEE AKVA TGRV LSLQ EEIA KLRK DLEQ TRSE KKCI EEHA DRYK QETE QLVS NLKE ENTL LKQE KEAL NHRI VQQA KEMT ETME KKLV EETK QLEL DLND ERLR YQNL LNEF SRLE ERYD DLKE EMTL MVHV PKPG HKRT DSTH SSNE SEYI FSSE IAEM EDIP SRTE EPSE KKVP L |
| 遺伝子ID: | 4644 |
| Uniprot: | Q9Y4I1 |
| セルラーロケーション: | |
| 計算された分子量: | 212kDa/215kDa/218kDa |
| 観察された分子量: | 240kDa |
| 同義語: | MYO5A, GS1, MYH12, MYO5, MYR12, myosin VA |
| バックグラウンド: | This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. |
| UniProt Protein Function: | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. |
| NCBI Summary: | This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9Y4I1 |
| NCBI GenInfo Identifier: | 215982791 |
| NCBI Gene ID: | 4644 |
| NCBI Accession: | NP_000250.3 |
| UniProt Secondary Accession: | Q9Y4I1,O60653, Q07902, Q16249, Q9UE30, Q9UE31, A8MZC5 |
| UniProt Related Accession: | Q9Y4I1 |
| Molecular Weight: | |
| NCBI Full Name: | unconventional myosin-Va isoform 1 |
| NCBI Synonym Full Names: | myosin VA |
| NCBI Official Symbol: | MYO5A |
| NCBI Official Synonym Symbols: | GS1; MYO5; MYH12; MYR12 |
| NCBI Protein Information: | unconventional myosin-Va |
| UniProt Protein Name: | Unconventional myosin-Va |
| UniProt Synonym Protein Names: | Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO5A |
 | Western blot analysis of extracts of various cell lines, using MYO5A antibody (CAB9830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human rectum using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens). |