Anti-MYO1A Antibody (CAB9272)
- SKU:
- CAB9272
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYO1A Antibody |
| 抗体コード: | CAB9272 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-1043 of human MYO1A (NP_005370.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Jurkat, HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-1043 of human MYO1A (NP_005370.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VQKF LLGL KNNL PSTN VLDK TWPA APYK CLST ANQE LQQL FYQW KCKR FRDQ LSPK QVEI LREK LCAS ELFK GKKA SYPQ SVPI PFCG DYIG LQGN PKLQ KLKG GEEG PVLM AEAV KKVN RGNG KTSS RILL LTKG HVIL TDTK KSQA KIVI GLDN VAGV SVTS LKDG LFSL HLSE MSSV GSKG DFLL VSEH VIEL LTKM YRAV LDAT QRQL TVTV TEKF SVRF KENS VAVK VVQG PAGG DNSK LRYK KKGS HCLE VTVQ |
| 遺伝子ID: | 4640 |
| Uniprot: | Q9UBC5 |
| セルラーロケーション: | |
| 計算された分子量: | 118kDa |
| 観察された分子量: | 160kDa |
| 同義語: | MYO1A, BBMI, DFNA48, MIHC, MYHL, myosin IA |
| バックグラウンド: | This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. |
| UniProt Protein Function: | MYO1A: Involved in directing the movement of organelles along actin filaments (Potential). Defects in MYO1A are the cause of deafness autosomal dominant type 48 (DFNA48). DFNA48 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. |
| UniProt Protein Details: | Protein type:Actin-binding; Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q13-q14 Cellular Component: basolateral plasma membrane; brush border; cortical actin cytoskeleton; cytoplasm; filamentous actin; lateral plasma membrane; microvillus Biological Process: sensory perception of sound; vesicle localization Disease: Deafness, Autosomal Dominant 48 |
| NCBI Summary: | This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9UBC5 |
| NCBI GenInfo Identifier: | 13431715 |
| NCBI Gene ID: | 4640 |
| NCBI Accession: | Q9UBC5.1 |
| UniProt Secondary Accession: | Q9UBC5,Q9UQD7, |
| UniProt Related Accession: | Q9UBC5 |
| Molecular Weight: | 118,401 Da |
| NCBI Full Name: | Unconventional myosin-Ia |
| NCBI Synonym Full Names: | myosin IA |
| NCBI Official Symbol: | MYO1A |
| NCBI Official Synonym Symbols: | BBMI; MIHC; MYHL; DFNA48 |
| NCBI Protein Information: | unconventional myosin-Ia |
| UniProt Protein Name: | Unconventional myosin-Ia |
| UniProt Synonym Protein Names: | Brush border myosin I; BBM-I; BBMI; Myosin I heavy chain; MIHC |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO1A |
| UniProt Entry Name: | MYO1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MYO1A antibody (CAB9272) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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