Anti-MYL12B Antibody (CAB5104)
- SKU:
- CAB5104
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-MYL12B Antibody |
抗体コード: | CAB5104 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human MYL12B (NP_291024.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse lung, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human MYL12B (NP_291024.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSSK KAKT KTTK KRPQ RATS NVFA MFDQ SQIQ EFKE AFNM IDQN RDGF IDKE DLHD MLAS LGKN PTDA YLDA MMNE APGP INFT MFLT MFGE KLNG TDPE DVIR NAFA CFDE EATG TIQE DYLR ELLT TMGD RFTD EEVD ELYR EAPI DKKG NFNY IEFT RILK HGAK DKDD |
遺伝子ID: | 103910 |
Uniprot: | O14950 |
セルラーロケーション: | |
計算された分子量: | 19kDa |
観察された分子量: | 20kDa |
同義語: | MYL12B, MLC-B, MRLC2 |
バックグラウンド: |
UniProt Protein Function: | MRLC2: non-sarcomeric myosin regulatory light chain 2. Binds calcium and plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Phosphorylation of MLC-2 in the presence of calcium and calmodulin increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. Myosin is an hexamer of 2 heavy chains and 4 light chains. |
UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: cytosol Molecular Function:protein binding Biological Process: muscle contraction |
NCBI Summary: | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014] |
UniProt Code: | O14950 |
NCBI GenInfo Identifier: | 205829213 |
NCBI Gene ID: | 10627 |
NCBI Accession: | O14950.2 |
UniProt Secondary Accession: | O14950,Q13182, Q7Z5Z4, D3DUH6, |
UniProt Related Accession: | P19105 |
Molecular Weight: | 19,779 Da |
NCBI Full Name: | Myosin regulatory light chain 12B |
NCBI Synonym Full Names: | myosin light chain 12A |
NCBI Official Symbol: | MYL12A |
NCBI Official Synonym Symbols: | MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24 |
NCBI Protein Information: | myosin regulatory light chain 12A |
UniProt Protein Name: | Myosin regulatory light chain 12B |
UniProt Synonym Protein Names: | MLC-2A; MLC-2; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; MLC20; Myosin regulatory light chain MRLC2; SHUJUN-1 |
Protein Family: | Myosin regulatory |
UniProt Gene Name: | MYL12B |
UniProt Entry Name: | ML12B_HUMAN |
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