Anti-MYBPC2 Antibody (CAB6934)
- SKU:
- CAB6934
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MYBPC2 Antibody |
| 抗体コード: | CAB6934 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 912-1141 of human MYBPC2 (NP_004524.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse skeletal muscle, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 912-1141 of human MYBPC2 (NP_004524.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LSVQ IENM KDTA TIRI RVVE KAGP PINV MVKE VWGT NALV EWQA PKDD GNSE IMGY FVQK ADKK TMEW FNVY ERNR HTSC TVSD LIVG NEYY FRVY TENI CGLS DSPG VSKN TARI LKTG ITFK PFEY KEHD FRMA PKFL TPLI DRVV VAGY SAAL NCAV RGHP KPKV VWMK NKME IRED PKFL ITNY QGVL TLNI RRPS PFDA GTYT CRAV NELG EALA ECKL EVRV PQ |
| 遺伝子ID: | 4606 |
| Uniprot: | Q14324 |
| セルラーロケーション: | |
| 計算された分子量: | 128kDa |
| 観察された分子量: | 135kDa |
| 同義語: | MYBPC2, MYBPC, MYBPCF, fast-type |
| バックグラウンド: | This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. |
| UniProt Protein Function: | MYBPC2: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. |
| UniProt Protein Details: | Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: cytosol Molecular Function:protein binding; structural constituent of muscle; actin binding Biological Process: cell adhesion; muscle filament sliding |
| NCBI Summary: | This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q14324 |
| NCBI GenInfo Identifier: | 296439237 |
| NCBI Gene ID: | 4606 |
| NCBI Accession: | Q14324.2 |
| UniProt Secondary Accession: | Q14324,A1L4G9, |
| UniProt Related Accession: | Q14324 |
| Molecular Weight: | 1141 |
| NCBI Full Name: | Myosin-binding protein C, fast-type |
| NCBI Synonym Full Names: | myosin binding protein C, fast type |
| NCBI Official Symbol: | MYBPC2 |
| NCBI Official Synonym Symbols: | MYBPC; MYBPCF |
| NCBI Protein Information: | myosin-binding protein C, fast-type; fast MyBP-C; C-protein, skeletal muscle fast isoform; fast-type muscle myosin-binding-protein C |
| UniProt Protein Name: | Myosin-binding protein C, fast-type |
| UniProt Synonym Protein Names: | C-protein, skeletal muscle fast isoform |
| Protein Family: | Myosin-binding protein |
| UniProt Gene Name: | MYBPC2 |
| UniProt Entry Name: | MYPC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MYBPC2 antibody (CAB6934) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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