Anti-MXD4 Antibody (CAB16485)
- SKU:
- CAB16485
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-MXD4 Antibody |
| 抗体コード: | CAB16485 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-209 of human MXD4 (NP_006445.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-209 of human MXD4 (NP_006445.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RRAL SIKE QLQQ EHRF LKRR LEQL SVQS VERV RTDS TGSA VSTD DSEQ EVDI EGME FGPG ELDS VGSS SDAD DHYS LQSG TGGD SGFG PHCR RLGR PALS |
| 遺伝子ID: | 10608 |
| Uniprot: | Q14582 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 30kDa |
| 同義語: | MXD4, MAD4, MST149, MSTP149, bHLHc12 |
| バックグラウンド: | This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. |
| UniProt Protein Function: | Mad4: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: nucleus Molecular Function:DNA binding; protein binding; protein dimerization activity; transcription corepressor activity Biological Process: negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14582 |
| NCBI GenInfo Identifier: | 5453734 |
| NCBI Gene ID: | 10608 |
| NCBI Accession: | NP_006445.1 |
| UniProt Secondary Accession: | Q14582,Q5TZX4, A2A335, |
| UniProt Related Accession: | Q14582 |
| Molecular Weight: | 23,528 Da |
| NCBI Full Name: | max dimerization protein 4 |
| NCBI Synonym Full Names: | MAX dimerization protein 4 |
| NCBI Official Symbol: | MXD4 |
| NCBI Official Synonym Symbols: | MAD4; MST149; MSTP149; bHLHc12 |
| NCBI Protein Information: | max dimerization protein 4 |
| UniProt Protein Name: | Max dimerization protein 4 |
| UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4 |
| Protein Family: | Max dimerization protein |
| UniProt Gene Name: | MXD4 |
| UniProt Entry Name: | MAD4_HUMAN |
 | Western blot analysis of extracts of mouse lung, using MXD4 antibody (CAB16485) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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