Anti-MVP Antibody (CAB1980)
- SKU:
- CAB1980
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-MVP Antibody |
抗体コード: | CAB1980 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MVP (NP_005106.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: | HT-29, A-549, BT-474, HeLa, HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MVP (NP_005106.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MATE EFII RIPP YHYI HVLD QNSN VSRV EVGP KTYI RQDN ERVL FAPM RMVT VPPR HYCT VANP VSRD AQGL VLFD VTGQ VRLR HADL EIRL AQDP FPLY PGEV LEKD ITPL QVVL PNTA LHLK ALLD FEDK DGDK VVAG DEWL FEGP GTYI PRKE VEVV EIIQ ATII RQNQ ALRL RARK ECWD RDGK ERVT GEEW LVTT VGAY LPAV FEEV LDLV DAVI LTEK TALH LRAR RNFR DFRG VSRR TGEE WLVT VQDT EAHV |
遺伝子ID: | 9961 |
Uniprot: | Q14764 |
セルラーロケーション: | Cytoplasm, Nucleus, nuclear pore complex |
計算された分子量: | 99kDa |
観察された分子量: | 100kDa |
同義語: | MVP, LRP, VAULT1 |
バックグラウンド: | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. |
UniProt Protein Function: | MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; nucleus; ribonucleoprotein complex Molecular Function:protein binding; protein phosphatase binding; protein kinase binding Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation |
NCBI Summary: | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
UniProt Code: | Q14764 |
NCBI GenInfo Identifier: | 21542417 |
NCBI Gene ID: | 9961 |
NCBI Accession: | Q14764.4 |
UniProt Secondary Accession: | Q14764,Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1, |
UniProt Related Accession: | Q14764 |
Molecular Weight: | 893 |
NCBI Full Name: | Major vault protein |
NCBI Synonym Full Names: | major vault protein |
NCBI Official Symbol: | MVP |
NCBI Official Synonym Symbols: | LRP; VAULT1 |
NCBI Protein Information: | major vault protein; lung resistance-related protein |
UniProt Protein Name: | Major vault protein |
UniProt Synonym Protein Names: | Lung resistance-related protein |
Protein Family: | Hyperpolarization-activated voltage-gated potassium channel |
UniProt Gene Name: | MVP |
UniProt Entry Name: | MVP_HUMAN |