Anti-MUS81 Antibody (CAB6818)
- SKU:
- CAB6818
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-MUS81 Antibody |
抗体コード: | CAB6818 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human MUS81 (NP_079404.3). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human MUS81 (NP_079404.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAP VRLG RKRP LPAC PNPL FVRW LTEW RDEA TRSR RRTR FVFQ KALR SLRR YPLP LRSG KEAK ILQH FGDG LCRM LDER LQRH RTSG GDHA PDSP SGEN SPAP QGRL AEVQ DSSM PVPA QPKA GGSG SYWP ARHS GARV ILLV LYRE HLNP NGHH FLTK EELL QRCA QKSP RVAP GSAR PWPA LRSL LHRN LVLR THQP ARYS LTPE GLEL AQKL AESE GLSL LNVG IGPK EPPG EETA VPGA ASAE LASE AGVQ QQPL ELRP GEYR VLLC VDIG ETRG GGHR PELL RELQ RLHV THTV RKLH VGDF VWVA QETN PRDP ANPG ELVL DHIV ERKR LDDL CSSI IDGR FR |
遺伝子ID: | 80198 |
Uniprot: | Q96NY9 |
セルラーロケーション: | Nucleus, nucleolus |
計算された分子量: | 61kDa |
観察された分子量: | 70kDa |
同義語: | MUS81, SLX3 |
バックグラウンド: | This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. |
UniProt Protein Function: | MUS81: Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the XPF family. |
UniProt Protein Details: | Protein type:Deoxyribonuclease; EC 3.1.22.-; Nucleolus Chromosomal Location of Human Ortholog: 11q13 Cellular Component: nucleolus; nucleus Molecular Function:protein binding; DNA binding; 3'-flap endonuclease activity; metal ion binding Biological Process: DNA repair; DNA catabolic process, endonucleolytic; DNA recombination |
UniProt Code: | Q96NY9 |
NCBI GenInfo Identifier: | 166898077 |
NCBI Gene ID: | 80198 |
NCBI Accession: | Q96NY9.3 |
UniProt Secondary Accession: | Q96NY9,Q9H7D9, |
UniProt Related Accession: | Q96NY9 |
Molecular Weight: | 551 |
NCBI Full Name: | Crossover junction endonuclease MUS81 |
NCBI Synonym Full Names: | MUS81 structure-specific endonuclease subunit |
NCBI Official Symbol: | MUS81 |
NCBI Official Synonym Symbols: | SLX3 |
NCBI Protein Information: | crossover junction endonuclease MUS81; MUS81 endonuclease homolog; SLX3 structure-specific endonuclease subunit homolog |
UniProt Protein Name: | Crossover junction endonuclease MUS81 |
Protein Family: | Crossover junction endonuclease |
UniProt Gene Name: | MUS81 |
UniProt Entry Name: | MUS81_HUMAN |
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