| UniProt Protein Function: | MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| UniProt Protein Details: | Protein type:Apoptosis; EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 1p36.12 Cellular Component: axon; cell soma; cytoplasm; integral to mitochondrial outer membrane; membrane; mitochondrion; nucleoplasm; peroxisome Molecular Function:identical protein binding; protein binding; signal transducer activity; SUMO ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: activation of JNK activity; caspase activation; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; negative regulation of defense response to virus by host; negative regulation of innate immune response; negative regulation of protein kinase B signaling cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein sumoylation; protein destabilization; protein stabilization; protein ubiquitination |
| UniProt Code: | Q969V5 |
| NCBI GenInfo Identifier: | 74760689 |
| NCBI Gene ID: | 79594 |
| NCBI Accession: | Q969V5.1 |
| UniProt Secondary Accession: | Q969V5,Q7Z431, Q9H9B5, B5M497, |
| UniProt Related Accession: | Q969V5 |
| Molecular Weight: | 39,800 Da |
| NCBI Full Name: | Mitochondrial ubiquitin ligase activator of NFKB 1 |
| NCBI Synonym Full Names: | mitochondrial E3 ubiquitin protein ligase 1 |
| NCBI Official Symbol: | MUL1 |
| NCBI Official Synonym Symbols: | GIDE; MAPL; MULAN; RNF218; C1orf166 |
| NCBI Protein Information: | mitochondrial ubiquitin ligase activator of NFKB 1 |
| UniProt Protein Name: | Mitochondrial ubiquitin ligase activator of NFKB 1 |
| UniProt Synonym Protein Names: | E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Mitochondrial-anchored protein ligase; MAPL; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1Curated |
| Protein Family: | Mitochondrial ubiquitin ligase activator |
| UniProt Gene Name: | MUL1 |
