| UniProt Protein Function: | Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. |
| NCBI Summary: | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q02817 |
| NCBI GenInfo Identifier: | 2506877 |
| NCBI Gene ID: | 4583 |
| NCBI Accession: | Q02817.2 |
| UniProt Secondary Accession: | Q02817,Q14878, |
| UniProt Related Accession: | Q02817 |
| Molecular Weight: | |
| NCBI Full Name: | Mucin-2 |
| NCBI Synonym Full Names: | mucin 2, oligomeric mucus/gel-forming |
| NCBI Official Symbol: | MUC2 |
| NCBI Official Synonym Symbols: | MLP; SMUC; MUC-2 |
| NCBI Protein Information: | mucin-2 |
| UniProt Protein Name: | Mucin-2 |
| UniProt Synonym Protein Names: | Intestinal mucin-2 |
| Protein Family: | Mucin |
| UniProt Gene Name: | MUC2 |
