Anti-MUC16 Antibody (CAB10005)
- SKU:
- CAB10005
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MUC16 Antibody |
| 抗体コード: | CAB10005 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 13965-14064 of human MUC16 (NP_078966.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 13965-14064 of human MUC16 (NP_078966.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QRSS LGAR YTGC RVIA LRSV KNGA ETRV DLLC TYLQ PLSG PGLP IKQV FHEL SQQT HGIT RLGP YSLD KDSL YLNG YNEP GPDE PPTT PKPA TTFL PPLS |
| 遺伝子ID: | 94025 |
| Uniprot: | Q8WXI7 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space |
| 計算された分子量: | 1519kDa |
| 観察された分子量: |
| 同義語: | MUC16, CA125, mucin-16 |
| バックグラウンド: | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
| UniProt Protein Function: | MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, peripheral; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extracellular space; extrinsic to membrane; Golgi lumen; plasma membrane; integral to membrane; vesicle Molecular Function:protein binding Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; cell adhesion; post-translational protein modification |
| UniProt Code: | Q8WXI7 |
| NCBI GenInfo Identifier: | 74716283 |
| NCBI Gene ID: | 94025 |
| NCBI Accession: | Q8WXI7.2 |
| UniProt Secondary Accession: | Q8WXI7,Q6ZQW5, Q96RK2, |
| UniProt Related Accession: | Q8WXI7 |
| Molecular Weight: | |
| NCBI Full Name: | Mucin-16 |
| NCBI Synonym Full Names: | mucin 16, cell surface associated |
| NCBI Official Symbol: | MUC16 |
| NCBI Official Synonym Symbols: | CA125 |
| NCBI Protein Information: | mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125 |
| UniProt Protein Name: | Mucin-16 |
| UniProt Synonym Protein Names: | Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125 |
| Protein Family: | Mucin |
| UniProt Gene Name: | MUC16 |
| UniProt Entry Name: | MUC16_HUMAN |
 | Immunohistochemistry of paraffin-embedded mouse lung using MUC16 antibody (CAB10005) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using MUC16 antibody (CAB10005) at dilution of 1:100 (40x lens). |
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