Anti-MTUS1 Antibody (CAB7601)
- SKU:
- CAB7601
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MTUS1 Antibody |
| 抗体コード: | CAB7601 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat spinal cord, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NAAH ETSK LEIE ASHS EKLE LLKK AYEA SLSE IKKG HEIE KKSL EDLL SEKQ ESLE KQIN DLKS ENDA LNEK LKSE EQKR RARE KANL KNPQ IMYL EQEL ESLK AVLE IKNE KLHQ QDIK LMKM EKLV DNNT ALVD KLKR FQQE NEEL KARM DKHM AISR QLST EQAV LQES LEKE SKVN KRLS MENE ELLW KLHN GDLC SPKR SPTS SAIP LQSP RNSG SFPS PSIS PR |
| 遺伝子ID: | 57509 |
| Uniprot: | Q9ULD2 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Golgi apparatus, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle |
| 計算された分子量: | 39-58kDa/84kDa/135kDa/141kDa |
| 観察された分子量: | 141kDa |
| 同義語: | MTUS1, ATBP, ATIP, ATIP3, ICIS, MP44, MTSG1 |
| バックグラウンド: | This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. |
| UniProt Protein Function: | MTUS1: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Defects in MTUS1 may be a cause of hepatocellular carcinoma (HCC). Belongs to the MTUS1 family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Mitochondrial Chromosomal Location of Human Ortholog: 8p22 Cellular Component: extracellular space |
| NCBI Summary: | This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULD2 |
| NCBI GenInfo Identifier: | 158706128 |
| NCBI Gene ID: | 57509 |
| NCBI Accession: | Q9ULD2.2 |
| UniProt Secondary Accession: | Q9ULD2,Q63HJ6, Q659F4, Q6PK49, Q6URW7, Q8N4M6, A8K135 B2RBJ6, B3KWJ9, B4DH03, B9EGA1, D3DSP8, |
| UniProt Related Accession: | Q9ULD2 |
| Molecular Weight: | 48,050 Da |
| NCBI Full Name: | Microtubule-associated tumor suppressor 1 |
| NCBI Synonym Full Names: | microtubule associated tumor suppressor 1 |
| NCBI Official Symbol: | MTUS1 |
| NCBI Official Synonym Symbols: | ATBP; ATIP; ICIS; MP44; MTSG1 |
| NCBI Protein Information: | microtubule-associated tumor suppressor 1 |
| UniProt Protein Name: | Microtubule-associated tumor suppressor 1 |
| UniProt Synonym Protein Names: | AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Mitochondrial tumor suppressor 1 |
| Protein Family: | Microtubule-associated tumor suppressor |
| UniProt Gene Name: | MTUS1 |
| UniProt Entry Name: | MTUS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTUS1 antibody (CAB7601) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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