Anti-MTPAP Antibody (CAB17715)
- SKU:
- CAB17715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-MTPAP Antibody |
| 抗体コード: | CAB17715 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, U-251MG, Jurkat, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MVIF FLQR RSPP ILPT LDSL KTLA DAED KCVI EGNN CTFV RDLS RIKP SQNT ETLE LLLK EFFE YFGN FAFD KNSI NIRQ GREQ NKPD SSPL YIQN PFET SLNI SKNV SQSQ LQKF VDLA RESA WILQ QEDT DRPS ISSN RPWG LVSL LLPS APNR KSFT KKKS NKFA IETV KNLL ESLK GNRT ENFT KTSG KRTI STQT |
| 遺伝子ID: | 55149 |
| Uniprot: | Q9NVV4 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 60kDa |
 | Western blot - MTPAP Polyclonal Antibody (CAB17715) |
| 同義語: | PAPD1, SPAX4, MTPAP |
| バックグラウンド: | The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011] |
| UniProt Protein Function: | PAPD1: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. Defects in MTPAP are the cause of spastic ataxia autosomal recessive type 4 (SPAX4). A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy. Affected individuals exhibit a drastic decrease in poly(A) tail length of representative mitochondrial mRNA transcripts, including COX1 and RNA14 (PubMed:20970105). Belongs to the DNA polymerase type-B-like family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.7.19; RNA processing; Transferase Chromosomal Location of Human Ortholog: 10p11.23 Cellular Component: mitochondrion; intracellular membrane-bound organelle Molecular Function:polynucleotide adenylyltransferase activity; identical protein binding; protein binding; protein homodimerization activity; manganese ion binding; magnesium ion binding; ATP binding Biological Process: transcription, DNA-dependent; mRNA polyadenylation Disease: Spastic Ataxia 4, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q9NVV4 |
| NCBI GenInfo Identifier: | 74753002 |
| NCBI Gene ID: | 55149 |
| NCBI Accession: | Q9NVV4.1 |
| UniProt Related Accession: | Q9NVV4 |
| Molecular Weight: | |
| NCBI Full Name: | Poly(A) RNA polymerase, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial poly(A) polymerase |
| NCBI Official Symbol: | MTPAP |
| NCBI Official Synonym Symbols: | PAPD1; SPAX4; TENT6 |
| NCBI Protein Information: | poly(A) RNA polymerase, mitochondrial |
| UniProt Protein Name: | Poly(A) RNA polymerase, mitochondrial |
| UniProt Synonym Protein Names: | PAP-associated domain-containing protein 1; Polynucleotide adenylyltransferase; Terminal uridylyltransferase 1; TUTase 1; mtPAP |
| Protein Family: | Poly(A) RNA polymerase |
| UniProt Gene Name: | MTPAP |
| UniProt Entry Name: | PAPD1_HUMAN |