Anti-MTNR1A Antibody (CAB13030)
- SKU:
- CAB13030
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MTNR1A Antibody |
| 抗体コード: | CAB13030 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-350 of human MTNR1A (NP_005949.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Mouse small intestine, Rat small intestine, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-350 of human MTNR1A (NP_005949.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | YYMA YFNS CLNA IIYG LLNQ NFRK EYRR IIVS LCTA RVFF VDSS NDVA DRVK WKPS PLMT NNNV VKVD SV |
| 遺伝子ID: | 4543 |
| Uniprot: | P48039 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 39kDa |
| 観察された分子量: | 39kDa |
| 同義語: | MTNR1A, MEL-1A-R, MT1 |
| バックグラウンド: | This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. |
| UniProt Protein Function: | MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:hormone binding; protein binding Biological Process: cell surface receptor linked signal transduction; G-protein signaling, coupled to cyclic nucleotide second messenger; mating behavior; positive regulation of cGMP biosynthetic process |
| NCBI Summary: | This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48039 |
| NCBI GenInfo Identifier: | 1346544 |
| NCBI Gene ID: | 4543 |
| NCBI Accession: | P48039.1 |
| UniProt Secondary Accession: | P48039,A0AVC5, B0M0L2, |
| UniProt Related Accession: | P48039 |
| Molecular Weight: | 39,375 Da |
| NCBI Full Name: | Melatonin receptor type 1A |
| NCBI Synonym Full Names: | melatonin receptor 1A |
| NCBI Official Symbol: | MTNR1A |
| NCBI Official Synonym Symbols: | MT1; MEL-1A-R |
| NCBI Protein Information: | melatonin receptor type 1A |
| UniProt Protein Name: | Melatonin receptor type 1A |
| Protein Family: | Melatonin receptor |
| UniProt Gene Name: | MTNR1A |
| UniProt Entry Name: | MTR1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTNR1A antibody (CAB13030) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Rat brain using MTNR1A antibody (CAB13030) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse brain using MTNR1A antibody (CAB13030) at dilution of 1:100 (40x lens). |
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