Anti-MTERF Antibody (CAB14805)
- SKU:
- CAB14805
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-MTERF Antibody |
抗体コード: | CAB14805 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 61-240 of human MTERF (NP_008911.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 61-240 of human MTERF (NP_008911.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KCHN TDSE PLKN EDLL KNLL TMGV DIDM ARKR QPGV FHRM ITNE QDLK MFLL SKGA SKEV IASI ISRY PRAI TRTP ENLS KRWD LWRK IVTS DLEI VNIL ERSP ESFF RSNN NLNL ENNI KFLY SVGL TRKC LCRL LTNA PRTF SNSL DLNK QMVE FLQA AGLS LGHN DPAD FVRK IIFK |
遺伝子ID: | 7978 |
Uniprot: | Q99551 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 45kDa |
観察された分子量: | 46kDa |
同義語: | MTERF1, MTERF |
バックグラウンド: | This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. |
UniProt Protein Function: | MTERF: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity. Belongs to the mTERF family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q21.2 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; double-stranded DNA binding Biological Process: termination of mitochondrial transcription; mitochondrion organization and biogenesis; regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; transcription termination; DNA geometric change; transcription from mitochondrial promoter |
NCBI Summary: | This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99551 |
NCBI GenInfo Identifier: | 5902010 |
NCBI Gene ID: | 7978 |
NCBI Accession: | NP_008911.1 |
UniProt Secondary Accession: | Q99551,Q32NF8, Q53H51, Q9BVR7, A4D1E3, |
UniProt Related Accession: | Q99551 |
Molecular Weight: | 45,778 Da |
NCBI Full Name: | transcription termination factor, mitochondrial |
NCBI Synonym Full Names: | mitochondrial transcription termination factor |
NCBI Official Symbol: | MTERF |
NCBI Protein Information: | transcription termination factor, mitochondrial; mitochondrial transcription termination factor 1 |
UniProt Protein Name: | Transcription termination factor, mitochondrial |
UniProt Synonym Protein Names: | Mitochondrial transcription termination factor 1 |
UniProt Gene Name: | MTERF |
UniProt Entry Name: | MTERF_HUMAN |
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