Anti-MTA2 Antibody (CAB10980)
- SKU:
- CAB10980
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MTA2 Antibody |
| 抗体コード: | CAB10980 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human MTA2 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:200 - 1:1000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of human MTA2 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9219 |
| Uniprot: | O94776 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 55kDa/75kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | MTA2, MTA1L1, PID |
| バックグラウンド: | This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. |
| UniProt Protein Function: | MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Deacetylase Chromosomal Location of Human Ortholog: 11q12-q13.1 Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; histone deacetylase complex; nuclear chromatin; NuRD complex Molecular Function:protein binding; nucleosomal DNA binding; zinc ion binding; histone deacetylase activity; transcription factor activity Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; ATP-dependent chromatin remodeling; DNA methylation; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011] |
| UniProt Code: | O94776 |
| NCBI GenInfo Identifier: | 29840793 |
| NCBI Gene ID: | 9219 |
| NCBI Accession: | O94776.1 |
| UniProt Related Accession: | O94776 |
| Molecular Weight: | Observed Molecular Weight: (Observed)75kD.Predicted Molecular Weight: (Calculated)75kDa. |
| NCBI Full Name: | Metastasis-associated protein MTA2 |
| NCBI Synonym Full Names: | metastasis associated 1 family member 2 |
| NCBI Official Symbol: | MTA2 |
| NCBI Official Synonym Symbols: | PID; MTA1L1 |
| NCBI Protein Information: | metastasis-associated protein MTA2 |
| UniProt Protein Name: | Metastasis-associated protein MTA2 |
| UniProt Synonym Protein Names: | Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex |
| Protein Family: | Metastasis-associated protein |
| UniProt Gene Name: | MTA2 |
| UniProt Entry Name: | MTA2_HUMAN |
 | Immunohistochemistry of paraffin-embedded human tonsil using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens). |
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