Anti-MT-ND5 Antibody (CAB17972)

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SKU:
CAB17972
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-MT-ND5 Antibody
抗体コード:CAB17972
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthetic peptide corresponding to a sequence within amino acids 510 to the C-terminus of human MT-ND5 (BAG14520.1).
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, HepG2, MCF7, mouse heart, mouse liver, rat liver
免疫原:A synthetic peptide corresponding to a sequence within amino acids 510 to the C-terminus of human MT-ND5 (BAG14520.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:LTNK LKMK SPLC TFYF SNML GFYP TITH RTIP YLGL LTSQ NLPL LLLD LTWL EKLL PKTI SQHQ ISTS IITS TQKG MIKL YFLS FFFP LILT LLLI T
遺伝子ID:4540
Uniprot:P03915
セルラーロケーション:
計算された分子量:67kDa
観察された分子量:67kDa
Anti-MT-ND5 Antibody (CAB17972)Western blot - MT-ND5 Rabbit pAb (CAB17972)
同義語:MTND5, MT-ND5
バックグラウンド:
UniProt Protein Function:MT-ND5: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND5 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND5 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ND5 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Defects in MT-ND5 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS). MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Belongs to the complex I subunit 5 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; EC 1.6.5.3; Mitochondrial

Chromosomal Location of Human Ortholog: -

Disease: Leber Optic Atrophy; Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes

UniProt Code:P03915
NCBI GenInfo Identifier:6648059
NCBI Gene ID:4540
NCBI Accession:P03915.2
UniProt Secondary Accession:P03915,Q34773, Q8WCY3,
Molecular Weight:67,027 Da
NCBI Full Name:NADH-ubiquinone oxidoreductase chain 5
NCBI Synonym Full Names:mitochondrially encoded NADH dehydrogenase 5
NCBI Official Symbol:MT-ND5  
NCBI Official Synonym Symbols:MTND5; ND5  
NCBI Protein Information:NADH dehydrogenase, subunit 5 (complex I)
UniProt Protein Name:NADH-ubiquinone oxidoreductase chain 5
UniProt Synonym Protein Names:NADH dehydrogenase subunit 5
UniProt Gene Name:MT-ND5  
UniProt Entry Name:NU5M_HUMAN
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