Anti-MSH5 Antibody (CAB10121)
- SKU:
- CAB10121
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-MSH5 Antibody |
| 抗体コード: | CAB10121 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MSH5 (NP_751897.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MSH5 (NP_751897.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASL GANP RRTP QGPR PGAA SSGF PSPA PVPG PREA EEEE VEEE EELA EIHL CVLW NSGY LGIA YYDT SDST IHFM PDAP DHES LKLL QRVL DEIN PQSV VTSA KQDE NMTR FLGK LASQ EHRE PKRP EIIF LPSV DFGL EISK QRLL SGNY SFIP DAMT ATEK ILFL SSII PFDC LLTV RALG GLLK FLGR RRIG VELE DYNV SVPI LGFK KFML THLV NIDQ DTYS VLQI FKSE SHPS VYKV ASGL KEGL SLFG ILNR |
| 遺伝子ID: | 4439 |
| Uniprot: | O43196 |
| セルラーロケーション: | |
| 計算された分子量: | 91kDa/92kDa/93kDa/94kDa |
| 観察された分子量: | 100kDa |
| 同義語: | MSH5, G7, MUTSH5, NG23, POF13 |
| バックグラウンド: | This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. |
| UniProt Protein Function: | MSH5: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis. Belongs to the DNA mismatch repair MutS family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: synaptonemal complex Molecular Function:damaged DNA binding; mismatched DNA binding; protein binding Biological Process: chiasma formation; meiotic mismatch repair; mismatch repair |
| NCBI Summary: | This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | O43196 |
| NCBI GenInfo Identifier: | 3914060 |
| NCBI Gene ID: | 4439 |
| NCBI Accession: | O43196.1 |
| UniProt Secondary Accession: | O43196,O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7, B0V033 B0V034, |
| UniProt Related Accession: | O43196 |
| Molecular Weight: | 91,862 Da |
| NCBI Full Name: | MutS protein homolog 5 |
| NCBI Synonym Full Names: | mutS homolog 5 |
| NCBI Official Symbol: | MSH5 |
| NCBI Official Synonym Symbols: | G7; NG23; MUTSH5 |
| NCBI Protein Information: | mutS protein homolog 5 |
| UniProt Protein Name: | MutS protein homolog 5 |
| Protein Family: | MutS protein |
| UniProt Gene Name: | MSH5 |
| UniProt Entry Name: | MSH5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MSH5 antibody (CAB10121) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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