| 同義語: | MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1 |
| バックグラウンド: | The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. |
| NCBI Summary: | The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q01362 |
| NCBI GenInfo Identifier: | 4503677 |
| NCBI Gene ID: | 2206 |
| NCBI Accession: | NP_000130.1 |
| UniProt Related Accession: | Q01362 |
| Molecular Weight: | |
| NCBI Full Name: | high affinity immunoglobulin epsilon receptor subunit beta isoform 1 |
| NCBI Synonym Full Names: | membrane spanning 4-domains A2 |
| NCBI Official Symbol: | MS4A2 |
| NCBI Official Synonym Symbols: | APY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B |
| NCBI Protein Information: | high affinity immunoglobulin epsilon receptor subunit beta |
| UniProt Protein Name: | High affinity immunoglobulin epsilon receptor subunit beta |
| UniProt Synonym Protein Names: | Fc epsilon receptor I beta-chain; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2 |
| Protein Family: | High affinity immunoglobulin epsilon receptor |
| UniProt Gene Name: | MS4A2 |
| UniProt Entry Name: | FCERB_HUMAN |
