Anti-MS4A2 Antibody (CAB8543)
- SKU:
- CAB8543
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-MS4A2 Antibody |
抗体コード: | CAB8543 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HL-60, Raji |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDTE SNRR ANLA LPQE PSSV PAFE VLEI SPQE VSSG RLLK SASS PPLH TWLT VLKK EQEF LGVT QILT AMIC LCFG TVVC SVLD ISHI EGDI FSSF KAGY |
遺伝子ID: | 2206 |
Uniprot: | Q01362 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 26kDa |
観察された分子量: | 27kDa |
同義語: | MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1 |
バックグラウンド: | The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. |
NCBI Summary: | The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q01362 |
NCBI GenInfo Identifier: | 4503677 |
NCBI Gene ID: | 2206 |
NCBI Accession: | NP_000130.1 |
UniProt Related Accession: | Q01362 |
Molecular Weight: | |
NCBI Full Name: | high affinity immunoglobulin epsilon receptor subunit beta isoform 1 |
NCBI Synonym Full Names: | membrane spanning 4-domains A2 |
NCBI Official Symbol: | MS4A2 |
NCBI Official Synonym Symbols: | APY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B |
NCBI Protein Information: | high affinity immunoglobulin epsilon receptor subunit beta |
UniProt Protein Name: | High affinity immunoglobulin epsilon receptor subunit beta |
UniProt Synonym Protein Names: | Fc epsilon receptor I beta-chain; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2 |
Protein Family: | High affinity immunoglobulin epsilon receptor |
UniProt Gene Name: | MS4A2 |
UniProt Entry Name: | FCERB_HUMAN |
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