| バックグラウンド: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q |
| UniProt Protein Function: | MRPS33: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. |
| UniProt Protein Details: | Protein type:Mitochondrial; Ribosomal Chromosomal Location of Human Ortholog: 7q34 Cellular Component: mitochondrial inner membrane; mitochondrion |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y291 |
| NCBI GenInfo Identifier: | 24212388 |
| NCBI Gene ID: | 51650 |
| NCBI Accession: | Q9Y291.1 |
| UniProt Related Accession: | Q9Y291 |
| Molecular Weight: | 12,629 Da |
| NCBI Full Name: | 28S ribosomal protein S33, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein S33 |
| NCBI Official Symbol: | MRPS33 |
| NCBI Official Synonym Symbols: | S33mt; PTD003; CGI-139; MRP-S33 |
| NCBI Protein Information: | 28S ribosomal protein S33, mitochondrial |
| UniProt Protein Name: | 28S ribosomal protein S33, mitochondrial |
| Protein Family: | 28S ribosomal protein |
| UniProt Gene Name: | MRPS33 |
| UniProt Entry Name: | RT33_HUMAN |
