Anti-MPP5 Antibody (CAB13878)
- SKU:
- CAB13878
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-MPP5 Antibody |
| 抗体コード: | CAB13878 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-576 of human MPP5 (NP_071919.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-576 of human MPP5 (NP_071919.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GDIL HVIS QEDP NWWQ AYRE GDED NQPL AGLV PGKS FQQQ REAM KQTI EEDK EPEK SGKL WCAK KNKK KRKK VLYN ANKN DDYD NEEI LTYE EMSL YHQP ANRK RPII LIGP QNCG QNEL RQRL MNKE KDRF ASAV PHTT RSRR DQEV AGRD YHFV SRQA FEAD IAAG KFIE HGEF EKNL YGTS IDSV RQVI NSGK ICLL S |
| 遺伝子ID: | 64398 |
| Uniprot: | Q8N3R9 |
| セルラーロケーション: | Cell junction, Cell membrane, Endomembrane system, Peripheral membrane protein, tight junction |
| 計算された分子量: | 73kDa/77kDa |
| 観察された分子量: | 77kDa |
| 同義語: | MPP5, PALS1, Mpp5 |
| バックグラウンド: | This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MPP5: May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. Belongs to the MAGUK family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q23.3 Cellular Component: nucleoplasm; protein complex; tight junction; lateral loop; cytoplasm; plasma membrane; endomembrane system Molecular Function:protein domain specific binding; protein binding Biological Process: intercellular junction assembly and maintenance; myelin formation; myelin maintenance in the peripheral nervous system; morphogenesis of an epithelial sheet |
| NCBI Summary: | This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q8N3R9 |
| NCBI GenInfo Identifier: | 116242632 |
| NCBI Gene ID: | 64398 |
| NCBI Accession: | Q8N3R9.3 |
| UniProt Related Accession: | Q8N3R9 |
| Molecular Weight: | 73kDa; 77kDa |
| NCBI Full Name: | MAGUK p55 subfamily member 5 |
| NCBI Synonym Full Names: | membrane palmitoylated protein 5 |
| NCBI Official Symbol: | MPP5 |
| NCBI Official Synonym Symbols: | PALS1 |
| NCBI Protein Information: | MAGUK p55 subfamily member 5 |
| UniProt Protein Name: | MAGUK p55 subfamily member 5 |
| Protein Family: | MAGUK p55 subfamily |
| UniProt Gene Name: | MPP5 |
| UniProt Entry Name: | MPP5_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using MPP5 antibody (CAB13878) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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