Anti-MMP19 Antibody (CAB6657)
- SKU:
- CAB6657
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-MMP19 Antibody |
| 抗体コード: | CAB6657 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human MMP19 (NP_002420.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human MMP19 (NP_002420.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IAAH EVGH ALGL GHSR YSQA LMAP VYEG YRPH FKLH PDDV AGIQ ALYG KKSP VIRD EEEE ETEL PTVP PVPT EPSP MPDP CSSE LDAM MLGP RGKT YAFK GDYV WTVS DSGP GPLF RVSA LWEG LPGN LDAA VYSP RTQW IHFF KGDK VWRY INFK MSPG FPKK LNRV EPNL DAAL YWPL NQKV FLFK GSGY WQWD ELAR TDFS SYPK PIKG LFTG VPNQ PSAA MSWQ DGRV YFFK GKVY WRLN QQLR VEKG YPRN ISHN WMHC RPRT IDTT PSGG NTTP SGTG ITLD TTLS ATET TFEY |
| 遺伝子ID: | 4327 |
| Uniprot: | Q99542 |
| セルラーロケーション: | Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 6kDa/25kDa/33kDa/57kDa |
| 観察された分子量: | 48kDa |
| 同義語: | MMP19, CODA, MMP18, RASI-1 |
| バックグラウンド: | This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. |
| UniProt Protein Function: | MMP19: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Protease; Secreted, signal peptide; EC 3.4.24.- Chromosomal Location of Human Ortholog: 12q14 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity Biological Process: extracellular matrix disassembly Disease: Cavitary Optic Disc Anomalies |
| NCBI Summary: | This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q99542 |
| NCBI GenInfo Identifier: | 12643345 |
| NCBI Gene ID: | 4327 |
| NCBI Accession: | Q99542.1 |
| UniProt Secondary Accession: | Q99542,O15278, O95606, Q99580, B4E030, |
| UniProt Related Accession: | Q99542 |
| Molecular Weight: | 33,793 Da |
| NCBI Full Name: | Matrix metalloproteinase-19 |
| NCBI Synonym Full Names: | matrix metallopeptidase 19 |
| NCBI Official Symbol: | MMP19 |
| NCBI Official Synonym Symbols: | CODA; MMP18; RASI-1 |
| NCBI Protein Information: | matrix metalloproteinase-19 |
| UniProt Protein Name: | Matrix metalloproteinase-19 |
| UniProt Synonym Protein Names: | Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP19 |
| UniProt Entry Name: | MMP19_HUMAN |
 | Western blot analysis of extracts of mouse lung, using MMP19 antibody (CAB6657) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose