Anti-MLLT4 Antibody (CAB18865)

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SKU:
CAB18865
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AF6
Synonyms:
MLL-AF6
Synonyms:
MLLT4
Synonyms:
l-afadin
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Description

抗体名:MLLT4 Rabbit pAb
抗体コード:CAB18865
サイズ:50uL, 100uL
同義語:AF6, MLL-AF6, MLLT4, l-afadin
申し込み:WB, IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of Human MLLT4.
申し込み:WB, IHC
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HT-29, Mouse lung
免疫原:Recombinant protein of Human MLLT4.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:4301
Uniprot:P55196
観察された分子量:200-250kDa
UniProt Protein Function:Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin. Protein type: Oncoprotein; Motility/polarity/chemotaxis; Cell adhesionChromosomal Location of Human Ortholog: 6q27Cellular Component: nucleoplasm; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; cytosol; cell junctionMolecular Function: protein C-terminus binding; protein binding; Ras GTPase binding; cell adhesion molecule bindingBiological Process: intercellular junction assembly and maintenance; cell-cell signaling; cell adhesion; signal transduction
UniProt Protein Details:
NCBI Summary:This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
UniProt Code:P55196
NCBI GenInfo Identifier:288558835
NCBI Gene ID:4301
NCBI Accession:P55196.3
UniProt Secondary Accession:P55196,O75087, O75088, O75089, Q59FP0, Q5TIG6, Q5TIG7 Q9NSN7, Q9NU92
UniProt Related Accession:P55196
Molecular Weight:1824
NCBI Full Name:Afadin
NCBI Synonym Full Names:myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Official Symbol:MLLT4  
NCBI Official Synonym Symbols:AF6  
NCBI Protein Information:afadin; protein AF-6; ALL1-fused gene from chromosome 6 protein
UniProt Protein Name:Afadin
UniProt Synonym Protein Names:ALL1-fused gene from chromosome 6 protein; Protein AF-6
Protein Family:Afadin
UniProt Gene Name:MLLT4  
UniProt Entry Name:AFAD_HUMAN
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