Anti-MLH3 Antibody (CAB7796)
- SKU:
- CAB7796
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-MLH3 Antibody |
| 抗体コード: | CAB7796 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1180-1429 of human MLH3 (NP_055196.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | MCF7, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1180-1429 of human MLH3 (NP_055196.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RFTK GMIH SMQV LQQV DNKF IACL MSTK TEEN GEAD SYEK QQAQ GSGR KKLL SSTL IPPL EITV TEEQ RRLL WCYH KNLE DLGL EFVF PDTS DSLV LVGK VPLC FVER EANE LRRG RSTV TKSI VEEF IREQ LELL QTTG GIQG TLPL TVQK VLAS QACH GAIK FNDG LSLQ ESCR LIEA LSSC QLPF QCAH GRPS MLPL ADID HLEQ EKQI KPNL TKLR KMAQ AWRL FGKA ECDT RQSL QQSM PPCE PP |
| 遺伝子ID: | 27030 |
| Uniprot: | Q9UHC1 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 161kDa/163kDa |
| 観察された分子量: | 164kDa |
| 同義語: | MLH3, HNPCC7 |
| バックグラウンド: | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. |
| UniProt Protein Function: | Probably involved in the repair of mismatches in DNA. |
| NCBI Summary: | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHC1 |
| NCBI GenInfo Identifier: | 91992162 |
| NCBI Gene ID: | 27030 |
| NCBI Accession: | NP_001035197.1 |
| UniProt Secondary Accession: | Q9UHC1,P49751, Q56DK9, Q9P292, Q9UHC0, |
| UniProt Related Accession: | Q9UHC1 |
| Molecular Weight: | 164 kD |
| NCBI Full Name: | DNA mismatch repair protein Mlh3 isoform 1 |
| NCBI Synonym Full Names: | mutL homolog 3 |
| NCBI Official Symbol: | MLH3 |
| NCBI Official Synonym Symbols: | HNPCC7 |
| NCBI Protein Information: | DNA mismatch repair protein Mlh3 |
| UniProt Protein Name: | DNA mismatch repair protein Mlh3 |
| UniProt Synonym Protein Names: | MutL protein homolog 3 |
| Protein Family: | DNA mismatch repair protein |
| UniProt Gene Name: | MLH3 |
 | Western blot analysis of extracts of various cell lines, using MLH3 antibody (CAB7796) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using MLH3 antibody (CAB7796) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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