Anti-MINPP1 Antibody (CAB10273)
- SKU:
- CAB10273
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MINPP1 Antibody |
| 抗体コード: | CAB10273 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 298-487 of human MINPP1 (NP_004888.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, U-87MG, SW620, HT-1080, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 298-487 of human MINPP1 (NP_004888.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KSPW CDVF DIDD AKVL EYLN DLKQ YWKR GYGY TINS RSSC TLFQ DIFQ HLDK AVEQ KQRS QPIS SPVI LQFG HAET LLPL LSLM GYFK DKEP LTAY NYKK QMHR KFRS GLIV PYAS NLIF VLYH CENA KTPK EQFR VQML LNEK VLPL AYSQ ETVS FYED LKNH YKDI LQSC QTSE ECEL ARAN STSD EL |
| 遺伝子ID: | 9562 |
| Uniprot: | Q9UNW1 |
| セルラーロケーション: | Endoplasmic reticulum lumen |
| 計算された分子量: | 31kDa/33kDa/34kDa/55kDa |
| 観察された分子量: | 50kDa |
| 同義語: | MINPP1, HIPER1, MINPP2, MIPP |
| バックグラウンド: | This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2, 3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway. |
| UniProt Protein Function: | MINPP1: Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). Defects in MINPP1 may be involved in follicular thyroid tumors development. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.80; Hydrolase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.1.3.62; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 10q23 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:acid phosphatase activity; phosphohistidine phosphatase activity Biological Process: bone mineralization; dephosphorylation; inositol phosphate metabolic process; ossification; polyphosphate metabolic process Disease: Thyroid Carcinoma, Follicular |
| NCBI Summary: | This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9UNW1 |
| NCBI GenInfo Identifier: | 68565617 |
| NCBI Gene ID: | 9562 |
| NCBI Accession: | Q9UNW1.1 |
| UniProt Secondary Accession: | Q9UNW1,O95172, O95286, Q59EJ2, Q9UGA3, F5H683, |
| UniProt Related Accession: | Q9UNW1 |
| Molecular Weight: | 33,100 Da |
| NCBI Full Name: | Multiple inositol polyphosphate phosphatase 1 |
| NCBI Synonym Full Names: | multiple inositol-polyphosphate phosphatase 1 |
| NCBI Official Symbol: | MINPP1 |
| NCBI Official Synonym Symbols: | MIPP; HIPER1; MINPP2 |
| NCBI Protein Information: | multiple inositol polyphosphate phosphatase 1 |
| UniProt Protein Name: | Multiple inositol polyphosphate phosphatase 1 |
| UniProt Synonym Protein Names: | 2,3-bisphosphoglycerate 3-phosphatase (EC:3.1.3.80); 2,3-BPG phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase |
| Protein Family: | Multiple inositol polyphosphate phosphatase |
| UniProt Gene Name: | MINPP1 |
| UniProt Entry Name: | MINP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MINPP1 antibody (CAB10273) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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