Anti-MIB2 Antibody (CAB17829)
- SKU:
- CAB17829
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-MIB2 Antibody |
| 抗体コード: | CAB17829 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, BxPC-3, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat brain, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ASVT WADG TTNV YRVG HKGK VDLK CVGE AAGG FYYK DHLP RLGK PAEL QRRV SADS QPFQ HGDK VKCL LDTD VLRE MQEG HGGW NPRM AEFI GQTG TVHR ITDR GDVR VQFN HETR WTFH PGAL TKHH SFWV GDVV RVIG DLDT VKRL QAGH GEWT DDMA PALG RVGK VVKV FGDG NLRV AVAG QRWT FSPS CLVA YRPE EDAN LDVA ERAR ENKS SLSV ALDK LRAQ KSDP EHPG RLVV EVAL GNAA RALD LLRR RPEQ VDTK NQGR TALQ VAAY LGQV E |
| 遺伝子ID: | 142678 |
| Uniprot: | Q96AX9 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 110kDa |
 | Western blot - MIB2 Polyclonal Antibody (CAB17829) |
| 同義語: | ZZANK1, ZZZ5, MIB2 |
| バックグラウンド: | The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017] |
| UniProt Protein Function: | MIB2: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. 9 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; signal transducer activity; ubiquitin-protein ligase activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination |
| UniProt Code: | Q96AX9 |
| NCBI GenInfo Identifier: | 209572707 |
| NCBI Gene ID: | 142678 |
| NCBI Accession: | Q96AX9.3 |
| UniProt Secondary Accession: | Q96AX9,Q7Z437, A2AGM5, A2AGM6, B3KV93, B3KVF4, B3KXY1 B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7, |
| UniProt Related Accession: | Q96AX9 |
| Molecular Weight: | 115,861 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase MIB2 |
| NCBI Synonym Full Names: | mindbomb E3 ubiquitin protein ligase 2 |
| NCBI Official Symbol: | MIB2 |
| NCBI Official Synonym Symbols: | ZZZ5; ZZANK1 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase MIB2 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase MIB2 |
| UniProt Synonym Protein Names: | Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | MIB2 |
| UniProt Entry Name: | MIB2_HUMAN |