Anti-MGAT5B Antibody (CAB13870)

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SKU:
CAB13870
Product type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-MGAT5B Antibody
抗体コード:CAB13870
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 616-790 of human MGAT5B (NP_653278.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Mouse
ポジティブサンプル:Mouse brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 616-790 of human MGAT5B (NP_653278.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:DPYL PYEY TCEG MLER IHAY IQHQ DFCR APDP ALPE AHAP QSPF VLAP NATH LEWA RNTS LAPG AWPP AHAL RAWL AVPG RACT DTCL DHGL ICEP SFFP FLNS QDAF LKLQ VPCD STES EMNH LYPA FAQP GQEC YLQK EPLL FSCA GSNT KYRR LCPC RDFR KGQV ALCQ GCL
遺伝子ID:146664
Uniprot:Q3V5L5
セルラーロケーション:Golgi apparatus membrane, Single-pass type II membrane protein
計算された分子量:89kDa/90kDa
観察された分子量:89kDa
同義語:MGAT5B, GnT-IX, GnT-VB, alpha-1
バックグラウンド:
UniProt Protein Function:MGAT5B: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. Belongs to the glycosyltransferase 18 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transferase; EC 2.4.1.155; Glycan Metabolism - N-glycan biosynthesis

Chromosomal Location of Human Ortholog: 17q25.2

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:protein binding; alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity; metal ion binding

Biological Process: protein amino acid N-linked glycosylation

NCBI Summary:The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
UniProt Code:Q3V5L5
NCBI GenInfo Identifier:152040009
NCBI Gene ID:146664
NCBI Accession:Q3V5L5.2
UniProt Related Accession:Q3V5L5
Molecular Weight:89kDa; 90kDa
NCBI Full Name:Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
NCBI Synonym Full Names:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
NCBI Official Symbol:MGAT5B  
NCBI Official Synonym Symbols:GnT-IX; GnT-VB  
NCBI Protein Information:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
UniProt Protein Name:Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
UniProt Synonym Protein Names:Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; GlcNAc-T Vb; GNT-Vb; hGnTVb; Mannoside acetylglucosaminyltransferase 5B; N-acetylglucosaminyl-transferase Vb; N-acetylglucosaminyltransferase IX; GNT-IX
Protein Family:Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
UniProt Gene Name:MGAT5B  
UniProt Entry Name:MGT5B_HUMAN
Anti-MGAT5B Antibody (CAB13870)Western blot analysis of extracts of mouse brain, using MGAT5B antibody (CAB13870) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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