| バックグラウンド: | This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1, 4 linkage to the Man-alpha-1, 3-Man-beta-1, 4-GlcNAc arm of R-Man-alpha-1, 6(GlcNAc-beta-1, 2-Man-alpha-1, 3)Man-beta-1, 4-GlcNAc-beta-1, 4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. |
| UniProt Protein Function: | Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis. |
| NCBI Summary: | This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQ53 |
| NCBI GenInfo Identifier: | 74735195 |
| NCBI Gene ID: | 11282 |
| NCBI Accession: | Q9UQ53.1 |
| UniProt Secondary Accession: | Q9UQ53,Q86TF1, Q96GH4, Q9NSK6, A8MPR0, |
| UniProt Related Accession: | Q9UQ53 |
| Molecular Weight: | 64,845 Da |
| NCBI Full Name: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| NCBI Synonym Full Names: | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B |
| NCBI Official Symbol: | MGAT4B |
| NCBI Official Synonym Symbols: | GNT-IV; GNT-IVB |
| NCBI Protein Information: | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| UniProt Protein Name: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| UniProt Synonym Protein Names: | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb |
| Protein Family: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| UniProt Gene Name: | MGAT4B |
| UniProt Entry Name: | MGT4B_HUMAN |
